Literature DB >> 10874514

Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury.

E J Coulson1, K Reid, S S Murray, S S Cheema, P F Bartlett.   

Abstract

1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down-regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor kappa B and c-jun), Bcl-2 family members and caspases.

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Year:  2000        PMID： 10874514     DOI： 10.1046/j.1440-1681.2000.03295.x

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  8 in total

Review 1.  Signaling of neuronal cell death by the p75NTR neurotrophin receptor.

Authors:  E J Coulson; K Reid; P F Bartlett
Journal:  Mol Neurobiol       Date:  1999-08       Impact factor: 5.590

2.  Neuroprotection by ulinastatin in experimental autoimmune encephalomyelitis.

Authors:  Yaqing Shu; Yu Yang; Wei Qiu; Zhengqi Lu; Ying Li; Jian Bao; Ming Feng; Xueqiang Hu
Journal:  Neurochem Res       Date:  2011-06-12       Impact factor: 3.996

3.  Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.

Authors:  Kanchana K Gamage; Irene Cheng; Rachel E Park; Mardeen S Karim; Kazusa Edamura; Christopher Hughes; Anthony J Spano; Alev Erisir; Christopher D Deppmann
Journal:  Curr Biol       Date:  2017-03-09       Impact factor: 10.834

4.  Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signaling cascades in the hippocampal CA1.

Authors:  Teresa Jover; Hidenobu Tanaka; Agata Calderone; Keiji Oguro; Michael V L Bennett; Anne M Etgen; R Suzanne Zukin
Journal:  J Neurosci       Date:  2002-03-15       Impact factor: 6.167

5.  Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury.

Authors:  Jing Zhang; Yi Li; Xuguang Zheng; Qi Gao; Zhongwu Liu; Runjiang Qu; Jade Borneman; Stanton B Elias; Michael Chopp
Journal:  J Neurosci Res       Date:  2008-05-15       Impact factor: 4.164

6.  Bone marrow stromal cell therapy reduces proNGF and p75 expression in mice with experimental autoimmune encephalomyelitis.

Authors:  Jing Zhang; Chaya Brodie; Yi Li; Xuguang Zheng; Cynthia Roberts; Mei Lu; Qi Gao; Jade Borneman; Smita Savant-Bhonsale; Stanton B Elias; Michael Chopp
Journal:  J Neurol Sci       Date:  2009-02-03       Impact factor: 3.181

7.  A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Authors:  Danielle A Simmons; Juliet K Knowles; Nadia P Belichenko; Gargi Banerjee; Carly Finkle; Stephen M Massa; Frank M Longo
Journal:  PLoS One       Date:  2014-08-25       Impact factor: 3.240

8.  A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Authors:  Danielle A Simmons; Nadia P Belichenko; Ellen C Ford; Sarah Semaan; Marie Monbureau; Sruti Aiyaswamy; Cameron M Holman; Christina Condon; Mehrdad Shamloo; Stephen M Massa; Frank M Longo
Journal:  Hum Mol Genet       Date:  2016-11-15       Impact factor: 6.150
  8 in total

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