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Literature DB >> 108737

Plasmatic renin activity in patients treated with L-dopa and inhibitor of dopa decarboxylase (IDC).

H Allain, J Van den Driessche, D Bentue-Ferrer, J M Reymann, D Pape, M Madigand.

Abstract

Plasmatic renin activity (PRA) was studied in patients receiving L-dopa, together with a decarboxylase inhibitor, at rest times and after periods of physical exertion. Although we can superimpose the results from unrelated Parkinson's disease patients on those of the control group, the results are inversed in stabilized patients (lowered PRA) and dyskinetic patients (increased PRA). There is a definite correlation between the increase in PRA and intensity of the dyskinesia. Dosage is the only other factor differentiating the two groups of Parkinsonians treated. The figures relative to arterial pressure are studied in the various groups.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 108737 DOI： 10.1007/bf00426736

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

23 in total

1. Studies concerning the mechanism of suppression of renin secretion by clonidine.

Authors: I A Reid; D M MacDonald; B Pachnis; W F Ganong
Journal: J Pharmacol Exp Ther Date: 1975-03 Impact factor: 4.030

2. Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data.

Authors: A R Cools; J M Van Rossum
Journal: Psychopharmacologia Date: 1976-02-02

Plasmatic renin activity in patients treated with L-dopa and inhibitor of dopa decarboxylase (IDC).

1. Studies concerning the mechanism of suppression of renin secretion by clonidine.

2. Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data.

3. ["Beginning and end of dose" dyskinesias caused by L-DOPA].

Review 4. Effects of angiotensin on the central nervous system.

5. Plasma renin activity during levodopa therapy. Significance of long- and short-term treatment.

6. Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.

7. Effect of L-DOPA on blood pressure and sympathetic nerve activity after decarboxylase inhibition in cats.

8. Plasma renin activity and levodopa in Parkinson's disease.

9. Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs.

10. Renin-aldosterone system in Parkinson's disease.

1. The use of bromocriptine for testing central dopaminergic reactivity.