| Literature DB >> 10872097 |
R Agarwal1, R Mittal, A Singh.
Abstract
High-potency adsorbates of chloroquine phosphate (CQP) were prepared by the batch method using a polyacrylic acid ion-exchange resin. Taste evaluation of the adsorbates shows significant masking of the bitterness of the drug. The complex formation was complete at pH 6.0. Stability studies at 37 degrees C, 45 degrees C, and 60 degrees C indicated that the complex was stable at all conditions for 1 month. In vitro release studies revealed complete drug elution from the complex at pH 1.2 and 2.0.Entities:
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Year: 2000 PMID： 10872097 DOI： 10.1081/ddc-100101297
Source DB: PubMed Journal: Drug Dev Ind Pharm ISSN： 0363-9045 Impact factor: 3.225