| Literature DB >> 10871875 |
A N Akbar1, J M Lord, M Salmon.
Abstract
The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.Entities:
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Year: 2000 PMID： 10871875 DOI： 10.1016/s0167-5699(00)01652-2
Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699