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Literature DB >> 108709

MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats.

Abstract

Pretreatment with the MAO-inhibitors iproniazid, clorgyline, or deprenyl abolishes the effects of LSD on the conditioned avoidance response (CAR) in rats. The effects of serotonin (5-HT) and 5-methoxytryptamine (5-MT) are greatly potentiated by these substances. Brain levels of LSD are not affected by MAO inhibition whereas levels of 5-HT and 5-MT are significantly elevated. It is postulated that the decreased behavioral response to LSD is the result of 'MAO inhibitor-induced' changes whereas the increased response of 5-HT and 5-MT results from increased brain levels of these compounds.

Entities: Chemical Gene Species

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Year: 1979 PMID： 108709 DOI： 10.1007/bf00426673

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

7 in total

5. Evidence of catecholamine mediation in the "aberrant" behaviour induced by lysergic acid diethylamide (LSD) in the rat.

Authors: A K Dixon
Journal: Experientia Date: 1968-07-15

6. The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.

Authors: H Y Yang; N H Neff
Journal: J Pharmacol Exp Ther Date: 1974-06 Impact factor: 4.030

7. Physiological disposition of beta-phenylethylamine, 2,4,5-trimethoxyphenylethylamine, 2,3,4,5,6-pentamethoxyphenylethylamine and beta-hydroxymescaline in rat brain, liver and plasma.

Authors: I Cohen; J F Fischer; W H Vogel
Journal: Psychopharmacologia Date: 1974-03-21

7 in total

1 in total

1. Effects of air ions on some aspects of learning and memory of rats and mice.

Authors: J M Olivereau; J F Lambert
Journal: Int J Biometeorol Date: 1981-03 Impact factor: 3.787

1 in total

MAO inhibition and the effects of centrally administered LSD, serotonin, and 5-methoxytryptamine on the conditioned avoidance response in rats.

1. THE EFFECT OF MAO INHIBITION ON THE EXPERIMENTAL PSYCHOSIS INDUCED BY DIMETHYLTRYPTAMINE.

2. LSD-25 ACTION IN NORMAL SUBJECTS TREATED WITH A MONOAMINE OXIDASE INHIBITOR.

3. The distribution and metabolism of lysergic acid diethylamide.

4. Deamination of 5-methoxytryptamine, serotonin and phenylethylamine by rat MAO in vitro and in vivo.

5. Evidence of catecholamine mediation in the "aberrant" behaviour induced by lysergic acid diethylamide (LSD) in the rat.

6. The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines.

7. Physiological disposition of beta-phenylethylamine, 2,4,5-trimethoxyphenylethylamine, 2,3,4,5,6-pentamethoxyphenylethylamine and beta-hydroxymescaline in rat brain, liver and plasma.

1. Effects of air ions on some aspects of learning and memory of rats and mice.