Literature DB >> 1087024

Role of antigenic structure in cell to cell cooperation.

M Schwartz, R J Hooghe, E Mozes, M Sela.   

Abstract

Two synthetic polypeptides which differ only in the order of amino acids in their NH2-terminal side chains, namely, (Tyr-Tyr-Glu-Glu)-poly(DLAla)- -poly(LLys) and (Tyr-Glu-Try-Glu)-poly(DLAla)- -poly(LLys), were found to be under different genetic control. By three different in vivo systems for thymus-derived cell depletion, it was demonstrated that (Tyr-Tyr-Glu-Glu)-poly(DLAla)- -poly(LLys), which represents the random poly(Tyr,Glu)-poly(DLAla)- -poly(Lys) in the pattern of immune responses and in the quality of antibodies they elicit, is thymus-dependent whereas (Tyr-Glu-Tyr-Glu)-poly(DLAla)-poly(LLys) does not require thymus-derived cell help for efficient antibody production. Therefore, the two ordered polypeptides which are similar chemically differ in parameters, not yet determined, which affect their capability to trigger bone marrow-derived cells.

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Year:  1976        PMID： 1087024      PMCID： PMC431377          DOI： 10.1073/pnas.73.11.4184

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Role of thymus-derived lymphocytes in the secondary humoral immune response in mice.

Authors:  M C Raff
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

2.  Role of optical configuration in the immunogenicity and specificity of synthetic antigens derived from multichain polyproline.

Authors:  J C Jaton; M Sela
Journal:  J Biol Chem       Date:  1968-11-10       Impact factor: 5.157

3.  Immunological unresponsiveness induced in adult mice to synthetic polypeptides built on multichain polyproline and multichain polyalanine.

Authors:  B Bonavida; E Mozes; G M Shearer; M Sela
Journal:  Immunochemistry       Date:  1974-07

4.  Studies on immunological paralysis. VI. Thymic-independence of tolerance and immunity to type 3 pneumococcal polysaccharide.

Authors:  J G Howard; G H Christie; B M Courtenay; E Leuchars; A J Davies
Journal:  Cell Immunol       Date:  1971-12       Impact factor: 4.868

5.  Thymus-independence of slowly metabolized immunogens.

Authors:  M Sela; E Mozes; G M Shearer
Journal:  Proc Natl Acad Sci U S A       Date:  1972-09       Impact factor: 11.205

6.  The role of thymus cells in the immune response to poly(Tyr, Glu)-polyD L Ala--polyLys as a function of the genetic constitution of the mouse strain.

Authors:  L Lichtenberg; E Mozes; G M Shearer; M Sela
Journal:  Eur J Immunol       Date:  1974-06       Impact factor: 5.532

7.  The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.

Authors:  M Feldmann; A Easten
Journal:  J Exp Med       Date:  1971-07-01       Impact factor: 14.307

8.  Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration.

Authors:  M Feldmann
Journal:  J Exp Med       Date:  1972-05-01       Impact factor: 14.307

9.  Antibody response of inbred mouse strains to ordered tetrapeptides of tyrosine and glutamic acid attached to multichain polyalanine or polyproline. Tyr-Tyr-Glu-Glu is a major determinant of the random poly-(Tyr, Glu)-polyDLAla--polyLys.

Authors:  E Mozes; M Schwartz; M Sela
Journal:  J Exp Med       Date:  1974-08-01       Impact factor: 14.307

10.  Contribution of different cell types to the genetic control of immune responses as a function of the chemical nature of the polymeric side chains (poly-L-prolyl and poly-DL-alanyl) of synthetic immunogens.

Authors:  G M Shearer; E Mozes; M Sela
Journal:  J Exp Med       Date:  1972-05-01       Impact factor: 14.307
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  6 in total

1.  Ia-antigen-T-cell interactions for a thymus-independent antigen composed of D amino acids.

Authors:  E Zisman; M Dayan; M Sela; E Mozes
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-01       Impact factor: 11.205

2.  Cellular analysis of specificity of antibodies and of delayed type hypersensitivity responses toward some structurally related synthetic antigens: boosting is determined by specificity of T cells.

Authors:  B Parhami-Seren; G Strassmann; E Mozes; M Sela
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

3.  The mode of interaction with macrophages of two ordered synthetic polypeptides which differ in their thymus dependency.

Authors:  M Schwartz; B Geiger; R Hooghe; M Bar-Eli; R Gallily; E Mozes; M Sela
Journal:  Immunology       Date:  1978-11       Impact factor: 7.397

4.  Change in specificity of antibodies to a random synthetic branched polypeptide in mice tolerant to its ordered analogs.

Authors:  M Schwartz; B Parhami; E Mozes; M Sela
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

5.  Antigen-reactive T clones. III. Low responder antigen-presenting cells function effectively to present antigen to selected T cell clones derived from (High Responder x Low Responder)F1 mice.

Authors:  M Kimoto; T J Krenz; C G Fathman
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307

6.  Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.

Authors:  A Singer; H B Dickler; R J Hodes
Journal:  J Exp Med       Date:  1977-10-01       Impact factor: 14.307
  6 in total

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