| Literature DB >> 10869731 |
Abstract
The endothelial cells release both relaxing [nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF), prostacyclin] and contracting factors [endoperoxides, thromboxane A(2), superoxide anions, endothelin-1 (ET)]. The production of ET is inhibited by NO. The latter also strongly opposes the direct effects of the former on vascular smooth muscle. With aging and vascular disease, the production of enothelial NO declines, and thus ET can be released, act and contribute to the symptoms.Entities:
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Year: 2000 PMID： 10869731 DOI： 10.1016/s0165-1838(00)00126-0
Source DB: PubMed Journal: J Auton Nerv Syst ISSN： 0165-1838