Literature DB >> 10869552

Secondary structure of the 5'-region of PGY1/MDR1 mRNA.

E V Kostenko1, R S Beabealashvilly, V V Vlassov, M A Zenkova.   

Abstract

In order to identify the optimal target sites for antisense oligonucleotides in the human multiple drug resistance mRNA, the secondary structure of the 5'-terminal part of this mRNA (nucleotides 1-678) was investigated. By using results of probing with ribonucleases T1, ONE and V1 and results of computer simulations, a model of the 5'-region of the PGY1/MDR1 mRNA was built. The molecule is formed by three major domains comprising several hairpins separated by single-stranded fragments. The predicted single-stranded regions of the PGY1/MDR1 mRNA efficiently bind complementary oligonucleotides.

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Year:  2000        PMID： 10869552     DOI： 10.1016/s0014-5793(00)01650-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  5'-bis-pyrenylated oligonucleotides displaying excimer fluorescence provide sensitive probes of RNA sequence and structure.

Authors:  E Kostenko; M Dobrikov; D Pyshnyi; V Petyuk; N Komarova; V Vlassov; M Zenkova
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

2.  Structure and dynamics of phosphate linkages and sugars in an abasic hexaloop RNA hairpin.

Authors:  Flore Joli; Edith Hantz; Brigitte Hartmann
Journal:  Biophys J       Date:  2005-12-02       Impact factor: 4.033

3.  Role of the highly structured 5'-end region of MDR1 mRNA in P-glycoprotein expression.

Authors:  Rebecca A Randle; Selina Raguz; Christopher F Higgins; Ernesto Yagüe
Journal:  Biochem J       Date:  2007-09-15       Impact factor: 3.857

4.  Solution structure of a purine rich hexaloop hairpin belonging to PGY/MDR1 mRNA and targeted by antisense oligonucleotides.

Authors:  Flore Joli; Nadia Bouchemal; Alain Laigle; Brigitte Hartmann; Edith Hantz
Journal:  Nucleic Acids Res       Date:  2006-10-13       Impact factor: 16.971

5.  Screening of deoxyribozyme with high reversal efficiency against multidrug resistance in breast carcinoma cells.

Authors:  Peng Gao; Jun-Min Wei; Peng-Yu Li; Cui-Juan Zhang; Wen-Cheng Jian; Yu-Hua Zhang; Ai-Yan Xing; Geng-Yin Zhou
Journal:  J Cell Mol Med       Date:  2011-10       Impact factor: 5.310
  5 in total

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