Literature DB >> 10869520

Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia.

A L Sica1, H E Greenberg, S M Scharf, D A Ruggiero.   

Abstract

Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical circuits that adaptively regulate sympathetic and cardiovascular activities.

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Year:  2000        PMID： 10869520     DOI： 10.1016/s0006-8993(00)02170-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


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