| Literature DB >> 10869200 |
P R Schmitzer1, P R Graupner, E L Chapin, S C Fields, J R Gilbert, J A Gray, C L Peacock, B C Gerwick.
Abstract
2,4-Dihydro-4-(beta-D-ribofuranosyl)-1,2,4(3H)-triazol-3-one (2) was identified as the principal phytotoxic component of a fermentation broth derived from an Actinomadura. The compound is a new natural product, but known by synthesis. Broad-spectrum herbicidal activity was demonstrated in greenhouse tests. Metabolite reversal studies suggested the target site was adenylosuccinate synthetase, which was confirmed by direct measurement of the activity of the 5'-phosphorylated derivative on the isolated enzyme.Entities:
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Year: 2000 PMID： 10869200 DOI： 10.1021/np990590i
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050