Regulatory variants for the expression of H-2 antigens. II. Level of discrimination of cell-mediated cytolysis.

We used alloantigenic variants to analyze whether killer T-cells and antibody in the presence of complement (two effector components of the immune system) recognized the same determinants on target tissues. The variants were selected from mouse myeloma cells by immune selection and differed from the parent cell in that they did not express H-2 antigens. The results suggested that both killer T-cells and humoral effectors recognized the same determinants, though the killer T-cells may have been more sensitive either in recognizing these determinants or mediating lysis.