Literature DB >> 1086885

Role of self-carriers in the immune response and tolerance. I. B-cell unresponsiveness and cytotoxic T-cell immunity induced by haptenated syngeneic lymphoid cells.

D W Scott, C A Long.   

Abstract

Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells,but go on to generate cytotoxic T cells directed at hapten-modified H-2.These results suggest that hapten-modifeid spleen cells may differentially induce B-cell tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.

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Year:  1976        PMID： 1086885      PMCID： PMC2190465          DOI： 10.1084/jem.144.5.1369

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  15 in total

1.  Hapten-specific tolerance: unresponsiveness in the T cell-depleted population.

Authors:  J A Hamilton; J F Miller
Journal:  Eur J Immunol       Date:  1973-07       Impact factor: 5.532

2.  Immunologic reactions to haptens on autologous carriers. II. Induction of hapten-specific tolerance and correlations between antibody response and antigen-driven cell proliferation in vitro.

Authors:  C S Walters; H N Claman
Journal:  J Immunol       Date:  1974-08       Impact factor: 5.422

3.  The effect of the carrier protein on the immune response and on the induction of tolerance in mice to the 2,4-dinitrophenyl determinant.

Authors:  H F Havas
Journal:  Immunology       Date:  1969-12       Impact factor: 7.397

4.  Specific inhibition of an anti-hapten immune response by chemical modifications of cells.

Authors:  D Naor; R I Mishell; L Wofsy
Journal:  J Immunol       Date:  1970-12       Impact factor: 5.422

5.  Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats.

Authors:  J C Howard; S V Hunt; J L Gowans
Journal:  J Exp Med       Date:  1972-02-01       Impact factor: 14.307

6.  Mechanism of immunologic unresponsiveness: a new approach.

Authors:  J R Battisto; B R Bloom
Journal:  Fed Proc       Date:  1966 Jan-Feb

Review 7.  Mechanism of lymphocyte-mediated cytolysis. The LMC cycle and its role in transplantation immunity.

Authors:  G Berke; D B Amos
Journal:  Transplant Rev       Date:  1973

8.  Radioresistance of the enhancing effect of cells from carrier-immunized mice in an in vitro primary immune response.

Authors:  J Kettman; R W Dutton
Journal:  Proc Natl Acad Sci U S A       Date:  1971-04       Impact factor: 11.205

9.  Antifluorescein affinity columns. Isolation and immunocompetence of lymphocytes that bind fluoresceinated antigens in vivo or in vitro.

Authors:  D W Scott
Journal:  J Exp Med       Date:  1976-07-01       Impact factor: 14.307

10.  Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten.

Authors:  D T Golan; Y Borel
Journal:  J Exp Med       Date:  1971-10-01       Impact factor: 14.307
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  8 in total

1.  Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance.

Authors:  Roberto A Maldonado; Robert A LaMothe; Joseph D Ferrari; Ai-Hong Zhang; Robert J Rossi; Pallavi N Kolte; Aaron P Griset; Conlin O'Neil; David H Altreuter; Erica Browning; Lloyd Johnston; Omid C Farokhzad; Robert Langer; David W Scott; Ulrich H von Andrian; Takashi Kei Kishimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-29       Impact factor: 11.205

2.  Induction of contact sensitivity. Selective induction of delayed hypersensitivity by the injection of cells from draining lymph nodes into the footpads of normal recipients.

Authors:  W R Thomas; G L Asherson; M A Perera
Journal:  Immunology       Date:  1978-04       Impact factor: 7.397

3.  Role of self carriers in the immune response and tolerance. V. Reversal of trinitrophenyl-modified self suppression of the B-cell response by blocking of H-2 antigens.

Authors:  J J Jandinski; J Li; P J Wettstein; J A Frelinger; D W Scott
Journal:  J Exp Med       Date:  1980-01-01       Impact factor: 14.307

4.  Regulation of T-cell-mediated lympholysis by the murine major histocompatibility complex. I. Preferential in vitro responses to trinitrophenyl-modified self K- and D-coded gene products in parental and F1 hybrid mouse strains.

Authors:  R B Levy; G M Shearer
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

5.  H-2-linked genetic control of murine T-cell-mediated lympholysis to autologous cells modified with low concentrations of trinitrobenzene sulfonate.

Authors:  G M Shearer; A M Schmitt-Verhulst; C B Pettinelli; M W Miller; P E Gilheany
Journal:  J Exp Med       Date:  1979-06-01       Impact factor: 14.307

6.  The induction of cell-mediated immunity and tolerance with protein antigens coupled to syngeneic lymphoid cells.

Authors:  S D Miller; R P Wetzig; H N Claman
Journal:  J Exp Med       Date:  1979-03-01       Impact factor: 14.307

7.  Mechanisms of idiotype suppression. IV. Functional neutralization in mixtures of idiotype-specific suppressor and hapten-specific suppressor T cells.

Authors:  B S Kim; J A Greenberg
Journal:  J Exp Med       Date:  1981-09-01       Impact factor: 14.307

8.  Two distinct mechanisms regulate the in vivo generation of cytotoxic T cells.

Authors:  M S Sy; S H Lee; M Tsurufuji; K L Rock; B Benacerraf; R Finberg
Journal:  J Exp Med       Date:  1982-09-01       Impact factor: 14.307
  8 in total

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