Literature DB >> 1086837

Biological relevance of gamma-ray-induced alkali-labile sites in single-stranded Dna in aqueous solutions.

M V Lafleur, M van Heuvel, H A van der Stroom, H Loman.   

Abstract

Gamma-irradiation in single-stranded phiX174 DNA in aqueous solution in the presence of oxygen produces at least two types of alkali-labile site. One is lethal and gives rise to single-strand breaks by treatment with alkali. The other is non-lethal, but is converted to lethal damage by alkali. The effect of alkali is dependent on temperature. This dependence is different for both types of alkali-labile site.

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Year:  1976        PMID: 1086837     DOI: 10.1080/09553007614551001

Source DB:  PubMed          Journal:  Int J Radiat Biol Relat Stud Phys Chem Med        ISSN: 0020-7616


  1 in total

1.  Some characteristics of apurinic sites in single- and double-stranded biologically active phi X174 DNA.

Authors:  M V Lafleur; J Woldhuis; H Loman
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

  1 in total

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