Literature DB >> 10866405

Functionalized nucleoside 5'-triphosphates for in vitro selection of new catalytic ribonucleic acids.

J Matulic-Adamic1, A T Daniher, A Karpeisky, P Haeberli, D Sweedler, L Beigelman.   

Abstract

A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were used to optimize the yields of these highly modified triphosphates.

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Year:  2000        PMID： 10866405     DOI： 10.1016/s0960-894x(00)00226-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Enhancing the catalytic repertoire of nucleic acids: a systematic study of linker length and rigidity.

Authors:  S E Lee; A Sidorov; T Gourlain; N Mignet; S J Thorpe; J A Brazier; M J Dickman; D P Hornby; J A Grasby; D M Williams
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

2.  Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR.

Authors:  T Gourlain; A Sidorov; N Mignet; S J Thorpe; S E Lee; J A Grasby; D M Williams
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes.

Authors:  Ralph E Kleiner; Yevgeny Brudno; Michael E Birnbaum; David R Liu
Journal:  J Am Chem Soc       Date:  2008-03-15       Impact factor: 15.419

4.  Selection, design, and characterization of a new potentially therapeutic ribozyme.

Authors:  Shawn P Zinnen; Kristal Domenico; Mike Wilson; Brent A Dickinson; Amber Beaudry; Victor Mokler; Andrew T Daniher; Alex Burgin; Leonid Beigelman
Journal:  RNA       Date:  2002-02       Impact factor: 4.942

5.  Substrate specificity and kinetic framework of a DNAzyme with an expanded chemical repertoire: a putative RNaseA mimic that catalyzes RNA hydrolysis independent of a divalent metal cation.

Authors:  Richard Ting; Jason M Thomas; Leonard Lermer; David M Perrin
Journal:  Nucleic Acids Res       Date:  2004-12-29       Impact factor: 16.971

6.  Challenging artificial genetic systems: thymidine analogs with 5-position sulfur functionality.

Authors:  Heike A Held; Steven A Benner
Journal:  Nucleic Acids Res       Date:  2002-09-01       Impact factor: 16.971

7.  In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors.

Authors:  Ralph E Kleiner; Christoph E Dumelin; Gerald C Tiu; Kaori Sakurai; David R Liu
Journal:  J Am Chem Soc       Date:  2010-08-25       Impact factor: 15.419

8.  Selectivity and affinity of DNA triplex forming oligonucleotides containing the nucleoside analogues 2'-O-methyl-5-(3-amino-1-propynyl)uridine and 2'-O-methyl-5-propynyluridine.

Authors:  Hong Li; Paul S Miller; Michael M Seidman
Journal:  Org Biomol Chem       Date:  2008-09-23       Impact factor: 3.876

9.  Diene-modified nucleotides for the Diels-Alder-mediated functional tagging of DNA.

Authors:  Vinciane Borsenberger; Stefan Howorka
Journal:  Nucleic Acids Res       Date:  2009-01-12       Impact factor: 16.971

10.  Sequence-specific cleavage of RNA in the absence of divalent metal ions by a DNAzyme incorporating imidazolyl and amino functionalities.

Authors:  Alexander V Sidorov; Jane A Grasby; David M Williams
Journal:  Nucleic Acids Res       Date:  2004-03-05       Impact factor: 16.971
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