Literature DB >> 10866404

Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase.

S W Lin1, Y L Lin, T C Lin, D Y Yang.   

Abstract

3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one has been found to be a new, potent, low molecular weight non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase with IC50 value of 30 nM. Preliminary studies suggest that the two carbonyl groups present in the compound are crucial for the inhibition activity.

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Year:  2000        PMID: 10866404     DOI: 10.1016/s0960-894x(00)00228-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Molecular docking analysis of nitisinone with homogentisate 1,2 dioxygenase.

Authors:  Narges Zolfaghari
Journal:  Bioinformation       Date:  2017-05-31
  1 in total

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