Literature DB >> 10866403

Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor.

H Takahata1, S Takahashi, N Azer, A T Eldefrawi, M E Eldefrawi.   

Abstract

The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.

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Year:  2000        PMID: 10866403     DOI: 10.1016/s0960-894x(00)00221-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B.

Authors:  Naoki Toyooka; Dejun Zhou; Hideo Nemoto; Yasuhiro Tezuka; Shigetoshi Kadota; Nirina R Andriamaharavo; H Martin Garraffo; Thomas F Spande; John W Daly
Journal:  J Org Chem       Date:  2009-09-04       Impact factor: 4.354

  1 in total

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