| Literature DB >> 10866393 |
J Cacciola1, J M Fevig, P F Stouten, R S Alexander, R M Knabb, R R Wexler.
Abstract
Conformationally restricted borolysine compounds containing a 2-(2-cyanophenylthio) benzoyl in the P3 position unexpectedly led to enhanced factor Xa inhibition. In an effort to improve both the potency and selectivity of this series by extending into the S' domain, we have replaced the boronic acid with alpha-ketoamides, utilizing a novel process that was developed in our labs.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10866393 DOI： 10.1016/s0960-894x(00)00215-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823