Literature DB >> 10866388

Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency.

F Leclercq1, C Dubertret, B Pitard, D Scherman, J Herscovici.   

Abstract

A safe and efficient synthesis of glycosylated polyethylenimine using titanium (IV) isopropoxide and sodium borohydride has been carried out as a substitute for the highly toxic sodium cyanoborohydride method currently used. Poryplexes formed between DNA and the various glycosylated polyethylenimines appeared to be much less cytotoxic than polyethylenimine (PEI)/DNA polyplexes.

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Year:  2000        PMID: 10866388     DOI: 10.1016/s0960-894x(00)00195-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  DNA-based therapeutics and DNA delivery systems: a comprehensive review.

Authors:  Siddhesh D Patil; David G Rhodes; Diane J Burgess
Journal:  AAPS J       Date:  2005-04-08       Impact factor: 4.009

Review 2.  Glycotargeting to improve cellular delivery efficiency of nucleic acids.

Authors:  Hongbin Yan; Kha Tram
Journal:  Glycoconj J       Date:  2007-02-01       Impact factor: 2.916

3.  Cytotoxic impacts of linear and branched polyethylenimine nanostructures in a431 cells.

Authors:  Vala Kafil; Yadollah Omidi
Journal:  Bioimpacts       Date:  2011-06-09

Review 4.  Nano-vectors for efficient liver specific gene transfer.

Authors:  Atul Pathak; Suresh P Vyas; Kailash C Gupta
Journal:  Int J Nanomedicine       Date:  2008
  4 in total

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