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Literature DB >> 10866386

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.

T Owa¹, T Okauchi, K Yoshimatsu, N H Sugi, Y Ozawa, T Nagasu, N Koyanagi, T Okabe, K Kitoh, H Yoshino.

Abstract

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Sulfonamides

Year: 2000 PMID： 10866386 DOI： 10.1016/s0960-894x(00)00219-5

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

6 in total

1. Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide).

Authors: Charlotte van Kesteren; R A A Mathôt; E Raymond; J P Armand; P Fumoleau; C Punt; M Ravic; J Wanders; J H Beijnen; J H M Schellens
Journal: Br J Clin Pharmacol Date: 2002-11 Impact factor: 4.335

2. Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam.

Authors: Charlotte van Kesteren; Anthe S Zandvliet; Mats O Karlsson; Ron A A Mathôt; Cornelis J A Punt; Jean-Pierre Armand; Eric Raymond; Alwin D R Huitema; Christian Dittrich; Herlinde Dumez; Henri H Roché; Jean-Pierre Droz; Miroslav Ravic; S Murray Yule; Jantien Wanders; Jos H Beijnen; Pierre Fumoleau; Jan H M Schellens
Journal: Invest New Drugs Date: 2005-06 Impact factor: 3.850

3. Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives.

Authors: Alessandra M T Souza; Helena C Castro; Monique A Brito; Carla R Andrighetti-Fröhner; Uiaran Magalhães; Kely N Oliveira; Daniela Gaspar-Silva; Letícia K Pacheco; Antônio C Joussef; Mário Steindel; Cláudia M O Simões; Dilvani O Santos; Magaly G Albuquerque; Carlos R Rodrigues; Ricardo J Nunes
Journal: Curr Microbiol Date: 2009-07-23 Impact factor: 2.188

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.

1. Development and validation of limited sampling strategies for prediction of the systemic exposure to the novel anticancer agent E7070 (N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide).

2. Semi-physiological model describing the hematological toxicity of the anti-cancer agent indisulam.

3. Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives.

4. Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol.

5. Inhibitors of tubulin assembly identified through screening a compound library.

Review 6. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones.