Literature DB >> 10866373

Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists.

N Fotouhi1, P Joshi, J W Tilley, K Rowan, V Schwinge, B Wolitzky.   

Abstract

Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependent on ring size and the position of the sulfur atom.

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Year:  2000        PMID： 10866373     DOI： 10.1016/s0960-894x(00)00175-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Strategies for recognition of stem-loop RNA structures by synthetic ligands: application to the HIV-1 frameshift stimulatory sequence.

Authors:  Prakash B Palde; Leslie O Ofori; Peter C Gareiss; Jaclyn Lerea; Benjamin L Miller
Journal:  J Med Chem       Date:  2010-08-26       Impact factor: 7.446

2.  Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin.

Authors:  Patrick J Knerr; Apostolia Tzekou; Daniel Ricklin; Hongchang Qu; Hui Chen; Wilfred A van der Donk; John D Lambris
Journal:  ACS Chem Biol       Date:  2011-05-23       Impact factor: 5.100

3.  Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin.

Authors:  Varsha R Jumde; Milon Mondal; Robin M Gierse; M Yagiz Unver; Francesca Magari; Roos C W van Lier; Andreas Heine; Gerhard Klebe; Anna K H Hirsch
Journal:  ChemMedChem       Date:  2018-10-09       Impact factor: 3.466

4.  Synthesis of novel sulfide-based cyclic peptidomimetic analogues to solonamides.

Authors:  José Brango-Vanegas; Luan A Martinho; Lucinda J Bessa; Andreanne G Vasconcelos; Alexandra Plácido; Alex L Pereira; José R S A Leite; Angelo H L Machado
Journal:  Beilstein J Org Chem       Date:  2019-10-25       Impact factor: 2.883
  4 in total

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