Literature DB >> 10866216

SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp. II. Structure determination.

C S Houge-Frydrych1, S A Readshaw, D J Bell.   

Abstract

A novel tyrosyl tRNA synthetase inhibitor, SB-219383, has been isolated from a Micromonospora sp. The structure of SB-219383 has been elucidated by a combination of derivatisation, spectroscopic and other analytical techniques and found to be N-(L-tyrosyl)-2-amino[1(S*),3(S*),4(S*),5(R*),8(R*)-2,4,5,8-tetrahydroxy -7-oxa-2-azabicyclo[3.2.1]oct-3-y1]acetic acid (1).

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Year:  2000        PMID: 10866216     DOI: 10.7164/antibiotics.53.351

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  5 in total

1.  Selective isolation and rapid identification of members of the genus Micromonospora.

Authors:  Danheng Qiu; Jisheng Ruan; Ying Huang
Journal:  Appl Environ Microbiol       Date:  2008-07-11       Impact factor: 4.792

2.  Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.

Authors:  Savitha Kalidas; Igor Cestari; Severine Monnerat; Qiong Li; Sandesh Regmi; Nicholas Hasle; Mehdi Labaied; Marilyn Parsons; Kenneth Stuart; Margaret A Phillips
Journal:  Eukaryot Cell       Date:  2014-02-21

3.  Bioprospecting Micromonospora from Kaziranga National Park of India and their anti-infective potential.

Authors:  Madhumita Talukdar; Aparajita Duarah; Shruti Talukdar; Manorama Bura Gohain; Rajal Debnath; Archana Yadav; Dhruva K Jha; Tarun C Bora
Journal:  World J Microbiol Biotechnol       Date:  2012-05-29       Impact factor: 3.312

4.  Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

Authors:  X Qiu; C A Janson; W W Smith; S M Green; P McDevitt; K Johanson; P Carter; M Hibbs; C Lewis; A Chalker; A Fosberry; J Lalonde; J Berge; P Brown; C S Houge-Frydrych; R L Jarvest
Journal:  Protein Sci       Date:  2001-10       Impact factor: 6.725

5.  Racemic methyl 3,10-dioxa-2-aza-tri-cyclo-[6.2.1.0]undecane-4-carboxyl-ate.

Authors:  Basem A Moosa; Atif Fazal; Shaikh A Ali; Mohammed Fettouhi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-04-29
  5 in total

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