Literature DB >> 10866208

Protein function in the post-genomic era.

D Eisenberg1, E M Marcotte, I Xenarios, T O Yeates.   

Abstract

Faced with the avalanche of genomic sequences and data on messenger RNA expression, biological scientists are confronting a frightening prospect: piles of information but only flakes of knowledge. How can the thousands of sequences being determined and deposited, and the thousands of expression profiles being generated by the new array methods, be synthesized into useful knowledge? What form will this knowledge take? These are questions being addressed by scientists in the field known as 'functional genomics'.

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Year:  2000        PMID: 10866208     DOI: 10.1038/35015694

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  188 in total

1.  DIP: The Database of Interacting Proteins: 2001 update.

Authors:  I Xenarios; E Fernandez; L Salwinski; X J Duan; M J Thompson; E M Marcotte; D Eisenberg
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

2.  Networking proteins in yeast.

Authors:  T R Hazbun; S Fields
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

3.  From proteases to proteomics.

Authors:  H Neurath
Journal:  Protein Sci       Date:  2001-04       Impact factor: 6.725

4.  Clinical practice in the new era. A fusion of molecular biology and classical medicine is transforming the way we look at and treat diseases.

Authors:  A G Papavassiliou
Journal:  EMBO Rep       Date:  2001-02       Impact factor: 8.807

5.  Relating whole-genome expression data with protein-protein interactions.

Authors:  Ronald Jansen; Dov Greenbaum; Mark Gerstein
Journal:  Genome Res       Date:  2002-01       Impact factor: 9.043

6.  Predictome: a database of putative functional links between proteins.

Authors:  Joseph C Mellor; Itai Yanai; Karl H Clodfelter; Julian Mintseris; Charles DeLisi
Journal:  Nucleic Acids Res       Date:  2002-01-01       Impact factor: 16.971

7.  An efficient algorithm for large-scale detection of protein families.

Authors:  A J Enright; S Van Dongen; C A Ouzounis
Journal:  Nucleic Acids Res       Date:  2002-04-01       Impact factor: 16.971

8.  Reverse engineering gene networks using singular value decomposition and robust regression.

Authors:  M K Stephen Yeung; Jesper Tegnér; James J Collins
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-30       Impact factor: 11.205

9.  Comparative analysis of chloroplast genomes: functional annotation, genome-based phylogeny, and deduced evolutionary patterns.

Authors:  Javier De Las Rivas; Juan Jose Lozano; Angel R Ortiz
Journal:  Genome Res       Date:  2002-04       Impact factor: 9.043

Review 10.  Genetic analysis of multiple sclerosis.

Authors:  Alastair Compston; Stephen Sawcer
Journal:  Curr Neurol Neurosci Rep       Date:  2002-05       Impact factor: 5.081

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