| Literature DB >> 10865454 |
P Dolara, B Corte, C Ghelardini, A M Pugliese, E Cerbai, S Menichetti, A Lo Nostro.
Abstract
We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.Entities:
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Year: 2000 PMID： 10865454 DOI： 10.1055/s-2000-8532
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352