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Literature DB >> 10865082

Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice.

Abstract

Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-10 in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 microg/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS.

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Year: 2000 PMID： 10865082 DOI： 10.1016/s0006-8993(00)02392-1

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

6 in total

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Authors: Sonu Singh; Akanksha Mishra; Neha Srivastava; Rakesh Shukla; Shubha Shukla
Journal: Mol Neurobiol Date: 2016-12-14 Impact factor: 5.590

2. Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis.

Authors: M Deckert; S Soltek; G Geginat; S Lütjen; M Montesinos-Rongen; H Hof; D Schlüter
Journal: Infect Immun Date: 2001-07 Impact factor: 3.441

6. Assessment of Extracellular Cytokines in the Hippocampus of the Awake Behaving Rat Using Large-Molecule Microdialysis Combined with Multiplex Arrays After Acute and Chronic Ethanol Exposure.

Authors: Anny Gano; Andrew S Vore; Maryam N Sammakia; Terrence Deak
Journal: Alcohol Clin Exp Res Date: 2019-02-11 Impact factor: 3.455

6 in total

Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice.

1. Acetyl-L-Carnitine via Upegulating Dopamine D1 Receptor and Attenuating Microglial Activation Prevents Neuronal Loss and Improves Memory Functions in Parkinsonian Rats.

2. Endogenous interleukin-10 is required for prevention of a hyperinflammatory intracerebral immune response in Listeria monocytogenes meningoencephalitis.

3. Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10.

4. Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide.

5. Exacerbated fatigue and motor deficits in interleukin-10-deficient mice after peripheral immune stimulation.

6. Assessment of Extracellular Cytokines in the Hippocampus of the Awake Behaving Rat Using Large-Molecule Microdialysis Combined with Multiplex Arrays After Acute and Chronic Ethanol Exposure.