SETTING: Korea University and the Korean Institute of Tuberculosis, Seoul, Korea. OBJECTIVE: To determine whether polymorphisms in the 3' untranslated region (UTR) of the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans. DESIGN: A case-control study design was used to compare the frequency of 3'UTR of NRAMP1 among 192 tuberculosis patients and 192 healthy individuals. All of the samples were diagnosed by X-ray, smear and culture tests between 1998 and 1999 in the Cross of Lorraine Clinic at the Korean Institute of Tuberculosis. RESULTS: A significant association was found between the Korean tuberculosis patients and polymorphisms in the 3'UTR of the NRAMP1 gene (odds ratio [OR] 1.845; 95% confidence interval [CI] 1.097-3.104; chi2 = 5.424; P = 0.020). CONCLUSION: This study showed that genetic variations in the human NRAMP1 gene are associated with susceptibility to smear-positive tuberculosis in Korean patients. The 3'UTR variant allele associated with susceptibility to tuberculosis is very uncommon in Caucasians, but is present in Koreans and West Africans. These observations may explain in part why African Americans and Koreans have greater susceptibility to tuberculosis than Caucasians.
SETTING: Korea University and the Korean Institute of Tuberculosis, Seoul, Korea. OBJECTIVE: To determine whether polymorphisms in the 3' untranslated region (UTR) of the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans. DESIGN: A case-control study design was used to compare the frequency of 3'UTR of NRAMP1 among 192 tuberculosispatients and 192 healthy individuals. All of the samples were diagnosed by X-ray, smear and culture tests between 1998 and 1999 in the Cross of Lorraine Clinic at the Korean Institute of Tuberculosis. RESULTS: A significant association was found between the Korean tuberculosispatients and polymorphisms in the 3'UTR of the NRAMP1 gene (odds ratio [OR] 1.845; 95% confidence interval [CI] 1.097-3.104; chi2 = 5.424; P = 0.020). CONCLUSION: This study showed that genetic variations in the humanNRAMP1 gene are associated with susceptibility to smear-positive tuberculosis in Korean patients. The 3'UTR variant allele associated with susceptibility to tuberculosis is very uncommon in Caucasians, but is present in Koreans and West Africans. These observations may explain in part why African Americans and Koreans have greater susceptibility to tuberculosis than Caucasians.
Authors: Suneil Malik; Laurent Abel; Heather Tooker; Audrey Poon; Leah Simkin; Manon Girard; Gerald J Adams; Jeffrey R Starke; Kimberly C Smith; Edward A Graviss; James M Musser; Erwin Schurr Journal: Proc Natl Acad Sci U S A Date: 2005-08-15 Impact factor: 11.205
Authors: Alison A Motsinger-Reif; Paulo R Z Antas; Noffisat O Oki; Shawn Levy; Steven M Holland; Timothy R Sterling Journal: BMC Med Genet Date: 2010-03-02 Impact factor: 2.103
Authors: P Niño-Moreno; D Portales-Pérez; B Hernández-Castro; L Portales-Cervantes; V Flores-Meraz; L Baranda; A Gómez-Gómez; V Acuña-Alonzo; J Granados; R González-Amaro Journal: Clin Exp Immunol Date: 2007-06 Impact factor: 4.330
Authors: Loukia-Maria Mitsos; Lon R Cardon; Lynn Ryan; Ronald LaCourse; Robert J North; Philippe Gros Journal: Proc Natl Acad Sci U S A Date: 2003-05-09 Impact factor: 11.205