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Literature DB >> 10862894

Lactic acid bacteria as a cell factory: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering.

Abstract

Lactic acid bacteria display a relatively simple metabolism wherein the sugar is converted mainly to lactic acid. The extensive knowledge of metabolic pathways and the increasing information of the genes involved allows for the rerouting of natural metabolic pathways by genetic and physiological engineering. We discuss several examples of metabolic engineering of Lactococcus lactis for the production of important compounds, including diacetyl, alanine and exopolysaccharides.

Entities: Chemical Species

Year: 2000 PMID： 10862894 DOI： 10.1016/s0141-0229(00)00180-0

Source DB: PubMed Journal: Enzyme Microb Technol ISSN： 0141-0229 Impact factor: 3.493

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Cited

22 in total

1. Multicopy integration of heterologous genes, using the lactococcal group II intron targeted to bacterial insertion sequences.

Authors: Helen Rawsthorne; Kevin N Turner; David A Mills
Journal: Appl Environ Microbiol Date: 2006-09 Impact factor: 4.792

2. In silico reconstruction of the metabolic pathways of Lactobacillus plantarum: comparing predictions of nutrient requirements with those from growth experiments.

Authors: Bas Teusink; Frank H J van Enckevort; Christof Francke; Anne Wiersma; Arno Wegkamp; Eddy J Smid; Roland J Siezen
Journal: Appl Environ Microbiol Date: 2005-11 Impact factor: 4.792

10. Coregulation of Terpenoid Pathway Genes and Prediction of Isoprene Production in Bacillus subtilis Using Transcriptomics.

Authors: Becky M Hess; Junfeng Xue; Lye Meng Markillie; Ronald C Taylor; H Steven Wiley; Birgitte K Ahring; Bryan Linggi
Journal: PLoS One Date: 2013-06-19 Impact factor: 3.240

Lactic acid bacteria as a cell factory: rerouting of carbon metabolism in Lactococcus lactis by metabolic engineering.

1. Multicopy integration of heterologous genes, using the lactococcal group II intron targeted to bacterial insertion sequences.

2. In silico reconstruction of the metabolic pathways of Lactobacillus plantarum: comparing predictions of nutrient requirements with those from growth experiments.

3. Regulation of acetate kinase isozymes and its importance for mixed-acid fermentation in Lactococcus lactis.

4. Evaluation of endogenous acidic metabolic products associated with carbohydrate metabolism in tumor cells.

Review 5. Recent advances in engineering the central carbon metabolism of industrially important bacteria.

6. Lactococcus lactis M4, a potential host for the expression of heterologous proteins.

7. Fine tuning of the lactate and diacetyl production through promoter engineering in Lactococcus lactis.

8. The relevance of genetic analysis to dairy bacteria: building upon our heritage.

9. Modeling Lactococcus lactis using a genome-scale flux model.

10. Coregulation of Terpenoid Pathway Genes and Prediction of Isoprene Production in Bacillus subtilis Using Transcriptomics.