Literature DB >> 10861657

Heterogeneity in Paget disease of the bone.

M A Nance1, F Q Nuttall, M J Econs, K W Lyles, K D Viles, J M Vance, M A Pericak-Vance, M C Speer.   

Abstract

Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity. Copyright 2000 Wiley-Liss, Inc.

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Year:  2000        PMID： 10861657     DOI： 10.1002/1096-8628(20000619)92:5<303::aid-ajmg2>3.0.co;2-e

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  3 in total

1.  Paget disease of bone: mapping of two loci at 5q35-qter and 5q31.

Authors:  N Laurin; J P Brown; A Lemainque; A Duchesne; D Huot; Y Lacourcière; G Drapeau; J Verreault; V Raymond; J Morissette
Journal:  Am J Hum Genet       Date:  2001-07-25       Impact factor: 11.025

2.  Genomewide search in familial Paget disease of bone shows evidence of genetic heterogeneity with candidate loci on chromosomes 2q36, 10p13, and 5q35.

Authors:  L J Hocking; C A Herbert; R K Nicholls; F Williams; S T Bennett; T Cundy; G C Nicholson; W Wuyts; W Van Hul; S H Ralston
Journal:  Am J Hum Genet       Date:  2001-09-05       Impact factor: 11.025

3.  Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.

Authors:  Nancy Laurin; Jacques P Brown; Jean Morissette; Vincent Raymond
Journal:  Am J Hum Genet       Date:  2002-04-30       Impact factor: 11.025
  3 in total

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