| Literature DB >> 10861641 |
Y Mori1, N Nishimoto, M Ohno, R Inagi, P Dhepakson, K Amou, K Yoshizaki, K Yamanishi.
Abstract
We found that human herpesvirus 8-encoded IL-6 (vIL-6) induced endogenous human IL-6 (huIL-6) secretion from various cell lines (MT-4, THP-1, U937, Raji, and CESS) including patients with multicentric Castleman's disease. Especially, in MT-4 cells, huIL-6 was enhanced with vIL-6 by 30-fold compared with that of control. In addition, reverse transcriptase-polymerase chain reaction confirmed that vIL-6 induced huIL-6 expression in MT-4 cells. Our novel finding of the huIL-6 induction by vIL-6 indicates that vIL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases. Copyright 2000 Wiley-Liss, Inc.Entities:
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Year: 2000 PMID： 10861641 DOI： 10.1002/1096-9071(200007)61:3<332::aid-jmv8>3.0.co;2-3
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327