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Literature DB >> 1086112

A comparative study of the effects of glutamate and kainate on the lobster muscle fibre and the frog spinal cord.

Abstract

1 The depolarizing actions of glutamate and its conformationally restricted analogue kainate were investigated on the lobster muscle fibre and the frog spinal cord using intracellular and extracellular recordings, respectively. 2 Bath-applied kainate was less potent than glutamate on the lobster fibre but more potent on the frog cord. From the log-log transformation of dose-response curves it was proposed that more than one glutamate molecule was necessary to activate both the lobster and the frog receptor sites. In the frog, at least three kainate molecules were thought to be required for receptor activation. 3 The ionic dependence of glutamate and kainate responses appeared different for the two tissues. 4 Some possible explanations of the differential tissue sensitivity to kainate are discussed.

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Year: 1976 PMID： 1086112 PMCID： PMC1667234 DOI： 10.1111/j.1476-5381.1976.tb07674.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

25 in total

9. A comparative study of the action of gamma-aminobutyric acid and piperazine on the lobster muscle fibre and the frog spinal cord.

Authors: A Constanti; A Nistri
Journal: Br J Pharmacol Date: 1976-07 Impact factor: 8.739

3. Acute effects of the neurotoxin kainic acid on neurons of the pigeon basal ganglia. Electrophysiological and light and electron microscopic observations.

Authors: G K Rieke; D E Bowers
Journal: Acta Neuropathol Date: 1982 Impact factor: 17.088

4. Antagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fibre and the frog spinal cord.

Authors: A Constanti; A Nistri
Journal: Br J Pharmacol Date: 1976-12 Impact factor: 8.739

5. Effects of glutamic acid analogues on identifiable giant neurones, sensitive to beta-hydroxy-L-glutamic acid, of an African giant snail (Achatina fulica Férussac).

Authors: T Nakajima; K Nomoto; Y Ohfune; Y Shiratori; T Takemoto; H Takeuchi; K Watanabe
Journal: Br J Pharmacol Date: 1985-11 Impact factor: 8.739

A comparative study of the effects of glutamate and kainate on the lobster muscle fibre and the frog spinal cord.

1. THE EFFECT ON CRAYFISH MUSCLE OF IONTOPHORETICALLY APPLIED GLUTAMATE.

2. Studies on convulsants in the isolated frog spinal cord. II. Effects on root potentials.

Review 3. Chemical transmission in invertebrate central nervous systems and neuromuscular junctions.

4. Reversal potentials of the excitatory transmitter and L-glutamate at the crayfish neuromuscular junction.

5. Actions of several anthelmintics and insecticides on rat cortical neurones.

6. Kainic acid: a powerful neurotoxic analogue of glutamate.

Review 7. Amino acid transmitters in the mammalian central nervous system.

8. The differential sensitivity of spinal interneurones and Renshaw cells to Kainate and N-methyl-D-aspartate.

9. A comparative study of the action of gamma-aminobutyric acid and piperazine on the lobster muscle fibre and the frog spinal cord.

10. Anion interaction at the inhibitory post-synaptic membrane of the crayfish neuromuscular junction.

Review 1. Mechanism of Neuroprotection Against Experimental Spinal Cord Injury by Riluzole or Methylprednisolone.

2. Effects of a spider toxin on the glutaminergic synapse of lobster muscle.

3. Acute effects of the neurotoxin kainic acid on neurons of the pigeon basal ganglia. Electrophysiological and light and electron microscopic observations.

4. Antagonism by some antihistamines of the amino acid-evoked responses recorded from the lobster muscle fibre and the frog spinal cord.

5. Effects of glutamic acid analogues on identifiable giant neurones, sensitive to beta-hydroxy-L-glutamic acid, of an African giant snail (Achatina fulica Férussac).

6. A study of the interactions between glutamate and aspartate at the lobster neuromuscular junction.

7. Further observations on the interaction between glutamate and aspartate on lobster muscle.

8. The role of the electrogenic sodium pump in the glutamate afterhyperpolarization of frog spinal cord.

9. A comparison of the action of glutamate, ibotenate and other related amino acids on feline spinal interneurones.