Literature DB >> 10860860

The LIM-domain protein FHL1 (SLIM 1) exhibits functional regulation in skeletal muscle.

P T Loughna1, P Mason, S Bayol, C Brownson.   

Abstract

The LIM domain protein FHL1 (SLIM 1) transcript is preferentially expressed in postnatal skeletal muscle but almost nothing is known about its function in this tissue. In this study we have examined the expression of the FHL1 transcript at the cellular level by in situ hybridisation. Muscle fibers exist as a number of discrete subpopulations or "types" which are differentiated by their contractile and metabolic properties. It was observed that the FHL1 transcript was not fiber-type specific but was however more abundant in oxidative fibers. Muscle atrophy induced by disuse caused a significant decline in the expression of the transcript but atrophy induced by short-term denervation did not. Hypertrophy of skeletal muscle induced by passive stretch was associated with an up-regulation of the FHL1 transcript. These data are consistent that FHL1 is involved in synthetic processes within the muscle fibre. Copyright 2000 Academic Press.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10860860     DOI： 10.1006/mcbr.2000.0206

Source DB:  PubMed          Journal:  Mol Cell Biol Res Commun        ISSN： 1522-4724


  14 in total

1.  Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis.

Authors:  Parveen Sharma; Thiruchelvi Shathasivam; Vladimir Ignatchenko; Thomas Kislinger; Anthony O Gramolini
Journal:  Mol Biosyst       Date:  2011-01-18

2.  A novel mutation in FHL1 in a family with X-linked scapuloperoneal myopathy: phenotypic spectrum and structural study of FHL1 mutations.

Authors:  Dong-Hui Chen; Wendy H Raskind; William W Parson; Joshua A Sonnen; Tiffany Vu; Yunlin Zheng; Mark Matsushita; John Wolff; Hillary Lipe; Thomas D Bird
Journal:  J Neurol Sci       Date:  2010-07-14       Impact factor: 3.181

3.  An X-linked myopathy with postural muscle atrophy and generalized hypertrophy, termed XMPMA, is caused by mutations in FHL1.

Authors:  Christian Windpassinger; Benedikt Schoser; Volker Straub; Sonja Hochmeister; Abdul Noor; Birgit Lohberger; Natalie Farra; Erwin Petek; Thomas Schwarzbraun; Lisa Ofner; Wolfgang N Löscher; Klaus Wagner; Hanns Lochmüller; John B Vincent; Stefan Quasthoff
Journal:  Am J Hum Genet       Date:  2008-01       Impact factor: 11.025

4.  Exome Sequencing Identified a Splice Site Mutation in FHL1 that Causes Uruguay Syndrome, an X-Linked Disorder With Skeletal Muscle Hypertrophy and Premature Cardiac Death.

Authors:  Yuan Xue; Benedikt Schoser; Aliz R Rao; Roberto Quadrelli; Alicia Vaglio; Verena Rupp; Christine Beichler; Stanley F Nelson; Gudrun Schapacher-Tilp; Christian Windpassinger; William R Wilcox
Journal:  Circ Cardiovasc Genet       Date:  2016-03-01

5.  Variations in the four and a half LIM domains 1 gene (FHL1) are associated with fasting insulin and insulin sensitivity responses to regular exercise.

Authors:  M Teran-Garcia; T Rankinen; T Rice; A S Leon; D C Rao; J S Skinner; C Bouchard
Journal:  Diabetologia       Date:  2007-06-23       Impact factor: 10.122

6.  Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.

Authors:  Chiao-nan Chen; Deborah A Ferrington; LaDora V Thompson
Journal:  J Appl Physiol (1985)       Date:  2008-08-28

7.  Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice.

Authors:  Andrea A Domenighetti; Pao-Hsien Chu; Tongbin Wu; Farah Sheikh; David S Gokhin; Ling T Guo; Ziyou Cui; Angela K Peter; Danos C Christodoulou; Michael G Parfenov; Joshua M Gorham; Daniel Y Li; Indroneal Banerjee; Xianyin Lai; Frank A Witzmann; Christine E Seidman; Jonathan G Seidman; Aldrin V Gomes; G Diane Shelton; Richard L Lieber; Ju Chen
Journal:  Hum Mol Genet       Date:  2013-08-23       Impact factor: 6.150

8.  Quantification of model and data uncertainty in a network analysis of cardiac myocyte mechanosignalling.

Authors:  Shulin Cao; Yasser Aboelkassem; Ariel Wang; Daniela Valdez-Jasso; Jeffrey J Saucerman; Jeffrey H Omens; Andrew D McCulloch
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2020-05-25       Impact factor: 4.226

9.  Tissue-Specific Effects of Loss of Estrogen during Menopause and Aging.

Authors:  Korinna Wend; Peter Wend; Susan A Krum
Journal:  Front Endocrinol (Lausanne)       Date:  2012-02-08       Impact factor: 5.555

10.  Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.

Authors:  Belinda S Cowling; Meagan J McGrath; Mai-Anh Nguyen; Denny L Cottle; Anthony J Kee; Susan Brown; Joachim Schessl; Yaqun Zou; Josephine Joya; Carsten G Bönnemann; Edna C Hardeman; Christina A Mitchell
Journal:  J Cell Biol       Date:  2008-12-15       Impact factor: 10.539
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.