Literature DB >> 10859464

Antigen recognition by human gammadelta T lymphocytes.

D Kabelitz1, A Glatzel, D Wesch.   

Abstract

Mature T lymphocytes carrying the conventional alphabeta T cell receptor (TCR) recognize peptide antigens in the context of MHC class I (CD8+) and MHC class II (CD4+) antigens, respectively. In striking contrast, human gammadelta T lymphocytes recognize unconventional antigens via their heterodimeric TCR in a non-MHC-restricted fashion. In this brief review, we discuss recent progress in the identification of ligands that are specifically recognized by human gammadelta T cells. It appears that gammadelta T cells have evolved to supplement the cellular immune response towards antigens that are not seen by alphabeta T lymphocytes. Copyright 2000 S. Karger AG, Basel

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Year:  2000        PMID： 10859464     DOI： 10.1159/000024353

Source DB:  PubMed          Journal:  Int Arch Allergy Immunol        ISSN： 1018-2438            Impact factor:   2.749


  32 in total

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