Literature DB >> 10858562

Extraordinarily high density of unrelated genes showing overlapping and intraintronic transcription units.

S R Misener1, V K Walker.   

Abstract

The cloning of pyrroline 5-carboxylate reductase from Drosophila melanogaster was accomplished by cDNA complementation of an Escherichia coli proline auxotroph. The corresponding P5cr gene is tightly clustered with three other expressed coding regions. A bidirectional promoter, an overlapping 3'UTR and an intraintronic sequence may all be found in only 4.3 kb, making this the most densely clustered region of unrelated genes in any eukaryote.

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Year:  2000        PMID: 10858562     DOI: 10.1016/s0167-4781(00)00096-8

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


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