Literature DB >> 10858352

Genetic organization of the downstream region of the mecA element in methicillin-resistant Staphylococcus aureus isolates carrying different polymorphisms of this region.

D C Oliveira1, S W Wu, H de Lencastre.   

Abstract

We describe here the genetic organization of the mec element downstream of the mecA gene in 34 different methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates carrying 13 of the most frequent polymorphisms of mecA and representing the major epidemic clones of MRSA. All polymorphisms carried three common genetic elements: the hypervariable region, a copy of IS431, and a unique 2-kb sequence (downstream constant segment, or dcs) for which no homologous sequences are found in data banks. Polymorphisms of the downstream region were shown to be caused by the presence of linearized plasmids flanked by insertion sequences (pUB110, pT181, and pI258) and the autonomous insertion sequence IS256.

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Year:  2000        PMID： 10858352      PMCID： PMC89983          DOI： 10.1128/AAC.44.7.1906-1910.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Wide geographic distribution of a unique methicillin-resistant Staphylococcus aureus clone in Hungarian hospitals.

Authors:  Herminia de Lencastre; Elena P. Severina; Hedda Milch; Marianne Konkoly Thege; Alexander Tomasz
Journal:  Clin Microbiol Infect       Date:  1997-06       Impact factor: 8.067

2.  The Staphylococcus aureus mec determinant comprises an unusual cluster of direct repeats and codes for a gene product similar to the Escherichia coli sn-glycerophosphoryl diester phosphodiesterase.

Authors:  C Ryffel; R Bucher; F H Kayser; B Berger-Bächi
Journal:  J Bacteriol       Date:  1991-12       Impact factor: 3.490

3.  Clonal distribution of methicillin-resistant Staphylococcus aureus in Poland.

Authors:  T Leski; D Oliveira; K Trzcinski; I S Sanches; M Aires de Sousa; W Hryniewicz; H de Lencastre
Journal:  J Clin Microbiol       Date:  1998-12       Impact factor: 5.948

4.  Intercontinental spread of a multidrug-resistant methicillin-resistant Staphylococcus aureus clone.

Authors:  M Aires de Sousa; I S Sanches; M L Ferro; M J Vaz; Z Saraiva; T Tendeiro; J Serra; H de Lencastre
Journal:  J Clin Microbiol       Date:  1998-09       Impact factor: 5.948

5.  Tracing the spread of methicillin-resistant Staphylococcus aureus by Southern blot hybridization using gene-specific probes of mec and Tn554.

Authors:  B N Kreiswirth; S M Lutwick; E K Chapnick; J D Gradon; L I Lutwick; D V Sepkowitz; W Eisner; M H Levi
Journal:  Microb Drug Resist       Date:  1995       Impact factor: 3.431

6.  Testing the efficacy of a molecular surveillance network: methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) genotypes in six hospitals in the metropolitan New York City area. The BARG Initiative Pilot Study Group. Bacterial Antibiotic Resistance Group.

Authors:  H de Lencastre; E P Severina; R B Roberts; B N Kreiswirth; A Tomasz
Journal:  Microb Drug Resist       Date:  1996       Impact factor: 3.431

7.  Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus.

Authors:  H de Lencastre; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

8.  Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315.

Authors:  T Ito; Y Katayama; K Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

9.  IS257 and small plasmid insertions in the mec region of the chromosome of Staphylococcus aureus.

Authors:  P R Stewart; D T Dubin; S G Chikramane; B Inglis; P R Matthews; S M Poston
Journal:  Plasmid       Date:  1994-01       Impact factor: 3.466

10.  Spread and maintenance of a dominant methicillin-resistant Staphylococcus aureus (MRSA) clone during an outbreak of MRSA disease in a Spanish hospital.

Authors:  M A Dominguez; H de Lencastre; J Linares; A Tomasz
Journal:  J Clin Microbiol       Date:  1994-09       Impact factor: 5.948
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  27 in total

1.  Comparison of DNA sequencing of the protein A gene polymorphic region with other molecular typing techniques for typing two epidemiologically diverse collections of methicillin-resistant Staphylococcus aureus.

Authors:  D C Oliveira; I Crisóstomo; I Santos-Sanches; P Major; C R Alves; M Aires-de-Sousa; M K Thege; H de Lencastre
Journal:  J Clin Microbiol       Date:  2001-02       Impact factor: 5.948

2.  Nosocomial spread of an unusual methicillin-resistant Staphylococcus aureus clone that is sensitive to all non-beta-lactam antibiotics, including tobramycin.

Authors:  S Pournaras; A Slavakis; A Polyzou; D Sofianou; A N Maniatis; A Tsakris
Journal:  J Clin Microbiol       Date:  2001-02       Impact factor: 5.948

3.  Recognition of two groups of methicillin-resistant Staphylococcus aureus strains based on epidemiology, antimicrobial susceptibility, hypervariable-region type, and ribotype in Finland.

Authors:  S Salmenlinna; J Vuopio-Varkila
Journal:  J Clin Microbiol       Date:  2001-06       Impact factor: 5.948

4.  Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus.

Authors:  Duarte C Oliveira; Hermínia de Lencastre
Journal:  Antimicrob Agents Chemother       Date:  2002-07       Impact factor: 5.191

5.  Genotyping of methicillin-resistant Staphylococcus aureus by assaying for the presence of variable elements associated with mecA.

Authors:  Flavia Huygens; Graeme R Nimmo; Jacqueline Schooneveldt; Wendy J Munckhof; Philip M Giffard
Journal:  J Clin Microbiol       Date:  2002-08       Impact factor: 5.948

6.  Systematic derivation of marker sets for staphylococcal cassette chromosome mec typing.

Authors:  Alex J Stephens; Flavia Huygens; Philip M Giffard
Journal:  Antimicrob Agents Chemother       Date:  2007-05-21       Impact factor: 5.191

7.  Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 Asian countries: a proposal for a new nomenclature for SCCmec elements.

Authors:  Piriyaporn Chongtrakool; Teruyo Ito; Xiao Xue Ma; Yoko Kondo; Suwanna Trakulsomboon; Chuntima Tiensasitorn; Mantana Jamklang; Tavinun Chavalit; Jae-Hoon Song; Keiichi Hiramatsu
Journal:  Antimicrob Agents Chemother       Date:  2006-03       Impact factor: 5.191

8.  Community-acquired methicillin-resistant Staphylococcus aureus, Finland.

Authors:  Saara Salmenlinna; Outi Lyytikäinen; Jaana Vuopio-Varkila
Journal:  Emerg Infect Dis       Date:  2002-06       Impact factor: 6.883

9.  A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus.

Authors:  Ulrich Nübel; Janina Dordel; Kevin Kurt; Birgit Strommenger; Henrik Westh; Sanjay K Shukla; Helena Zemlicková; Raphaël Leblois; Thierry Wirth; Thibaut Jombart; François Balloux; Wolfgang Witte
Journal:  PLoS Pathog       Date:  2010-04-08       Impact factor: 6.823

10.  Characterization of a new SCCmec element in Staphylococcus cohnii.

Authors:  Zhiyong Zong; Xiaoju Lü
Journal:  PLoS One       Date:  2010-11-17       Impact factor: 3.240
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