Literature DB >> 10857746

The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription.

A Hida1, N Koike, M Hirose, M Hattori, Y Sakaki, H Tei.   

Abstract

The clock gene, Period1, from human and mouse was sequenced and characterized. Both human PERIOD1 (human PER1) and mouse Period1 (mouse Per1) consisted of 23 exons spanning approximately 16 kb, and their structures showed strong similarity to each other. For example, six highly conserved regions were identified in the 5' upstream sequences. These conserved segments exhibited 77-88% identity and possessed several potential regulatory elements including five E-boxes (the binding site of the CLOCK-BMAL1 complex) and four cyclic AMP response elements. Transient transfection assays using a mPer1-luciferase fusion gene revealed that each of the conserved E-boxes additively functions as an enhancer for the transactivation of mPer1 by mCLOCK and mBMAL1.

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Year:  2000        PMID： 10857746     DOI： 10.1006/geno.2000.6166

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  46 in total

1.  Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators.

Authors:  N Le Minh; F Damiola; F Tronche; G Schütz; U Schibler
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

2.  Expression of Period genes: rhythmic and nonrhythmic compartments of the suprachiasmatic nucleus pacemaker.

Authors:  T Hamada; J LeSauter; J M Venuti; R Silver
Journal:  J Neurosci       Date:  2001-10-01       Impact factor: 6.167

3.  A negative regulatory element required for light-dependent pinopsin gene expression.

Authors:  Yoko Takanaka; Toshiyuki Okano; Kazuyuki Yamamoto; Yoshitaka Fukada
Journal:  J Neurosci       Date:  2002-06-01       Impact factor: 6.167

4.  Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells.

Authors:  Xiaorong Liu; Carla B Green
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

5.  Stoichiometric relationship among clock proteins determines robustness of circadian rhythms.

Authors:  Yongjin Lee; Rongmin Chen; Hyeong-min Lee; Choogon Lee
Journal:  J Biol Chem       Date:  2011-01-03       Impact factor: 5.157

Review 6.  Circadian mRNA expression: insights from modeling and transcriptomics.

Authors:  Sarah Lück; Pål O Westermark
Journal:  Cell Mol Life Sci       Date:  2015-10-26       Impact factor: 9.261

7.  RACK1, a novel hPER1-interacting protein.

Authors:  Lijuan Hu; Fang Lu; Yuhui Wang; Yanyou Liu; Desang Liu; Zhou Jiang; Chaomin Wan; Bin Zhu; Lu Gan; Yueqi Wang; Zhengrong Wang
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

8.  Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity.

Authors:  Natsuko Inagaki; Sato Honma; Daisuke Ono; Yusuke Tanahashi; Ken-ichi Honma
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-26       Impact factor: 11.205

9.  Circadian rhythms in isolated brain regions.

Authors:  Michikazu Abe; Erik D Herzog; Shin Yamazaki; Marty Straume; Hajime Tei; Yoshiyuki Sakaki; Michael Menaker; Gene D Block
Journal:  J Neurosci       Date:  2002-01-01       Impact factor: 6.167

Review 10.  Vasoactive intestinal peptide and the mammalian circadian system.

Authors:  Andrew M Vosko; Analyne Schroeder; Dawn H Loh; Christopher S Colwell
Journal:  Gen Comp Endocrinol       Date:  2007-05-26       Impact factor: 2.822
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