Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats.

Literature DB >> 10854726

Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats.

Y J Ho¹, Y C Chang, T M Liu, M Y Tai, C S Wong, Y F Tsai.

Abstract

Striatal glutamate release during novelty exposure-induced hyperactivity was studied by microdialysis in freely-moving olfactory bulbectomized (OBX) rats. After collecting three 10 min basal striatal dialysate samples, the animals were transferred to an open-field apparatus (novelty) and locomotor activity recorded for 60 min. OBX rats showed significantly more locomotor activity (1210+/-270 cm) than sham-operated rats (420+/-70 cm), but only in the first 10 min after exposure to the novel environment. During the same period, striatal glutamate levels increased to 163+/-21% of the basal value in OBX rats, while no changes were seen in the striatum of sham-operated controls. These findings suggest that olfactory bulbectomy results in an increased response of the striatal glutamatergic system to novelty stress, and may consequently cause hyperactivity.

Entities: Chemical Disease Species

Mesh：

Substances：
Glutamic Acid

Year: 2000 PMID： 10854726 DOI： 10.1016/s0304-3940(00)01152-6

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

Keyword Cloud
Cited

7 in total

1. Tangeretin inhibits neurodegeneration and attenuates inflammatory responses and behavioural deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease dementia in rats.

Authors: Jin-Song Yang; Xiao-Hong Wu; Hao-Gang Yu; Li-Song Teng
Journal: Inflammopharmacology Date: 2017-06-02 Impact factor: 4.473

2. Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.

Authors: Sarah A Eisenstein; Philip V Holmes; Andrea G Hohmann
Journal: Synapse Date: 2009-11 Impact factor: 2.562

3. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.

Authors: Sarah A Eisenstein; Jason R Clapper; Philip V Holmes; Daniele Piomelli; Andrea G Hohmann
Journal: Pharmacol Res Date: 2010-01-05 Impact factor: 7.658

7. Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats.

Authors: Yan Pan; Yemiliya Berman; Kenneth D Carr
Journal: BMC Neurosci Date: 2004-12-03 Impact factor: 3.288

7 in total

Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats.

1. Tangeretin inhibits neurodegeneration and attenuates inflammatory responses and behavioural deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease dementia in rats.

2. Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation.

3. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.

4. Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner.

5. Medium- and high-intensity rTMS reduces psychomotor agitation with distinct neurobiologic mechanisms.

6. Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level.

7. Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats.