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Literature DB >> 1085412

Phospholipids bound to acidic nuclear proteins in human B and T lymphocytes.

F A Manzoli, L Cocco, A Facchini, A M Casali, N M Maraldi, C E Grossi.

Abstract

Chromatin fractions (DNA, histones and non-histone chromosomal proteins NHCP) have been isolated from human peripheral B and T lymphocytes using different methods and analyzed in order to identify their lipid content. While DNA and histone fractions do not reveal the presence of lipids, a 2% of phospholipids is present in the NHCP fraction. The phospholipids associated with NHCP present a constant relative ratio among sphingomyelin, phosphatidyl-choline and phosphatidyl-ethanolamine both in B and T lymphocytes, whichever are the extraction procedures employed. These findings are related to the possible dereprssive role of phospholipids on DNA-dependent RNA synthesis.

Entities: Chemical Species

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Year: 1976 PMID： 1085412 DOI： 10.1007/bf01731551

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

29 in total

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Journal: Boll Ist Sieroter Milan Date: 1974

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Journal: Clin Exp Immunol Date: 1969-04 Impact factor: 4.330

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Authors: V G Allfrey; A Inoue; J Karn; E M Johnson; G Vidali
Journal: Cold Spring Harb Symp Quant Biol Date: 1974

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Authors: A Lezius; B Müller-Lornsen
Journal: Hoppe Seylers Z Physiol Chem Date: 1972-12

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Authors: K R Shelton; V G Allfrey
Journal: Nature Date: 1970-10-10 Impact factor: 49.962

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Authors: L M Shaw; R C Huang
Journal: Biochemistry Date: 1970-11-10 Impact factor: 3.162

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Authors: F A Manzoli; M Gelli
Journal: Arch Oral Biol Date: 1968-06 Impact factor: 2.633

4 in total

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Authors: Hongyan Yao; Geliang Wang; Liang Guo; Xuemin Wang
Journal: Plant Cell Date: 2013-12-24 Impact factor: 11.277