Literature DB >> 1085404

Methotrexate megadosage followed by folate rescue. I. A study in clearance patterns.

S Salasoo, M G Irving, R Lam-Po0Tang, D O'Gorman-Hughes, A Freedman.   

Abstract

Plasma clearance rates of methotrexate (MTX) have been determined in five patients given an infusion of 3,000 mg of MTX over six hours, followed by folate rescue 24 hours after the commencement of infusion. Results presented indicate that maintenance of high MTX concentrations and potential toxicity could not be related to age, body weight or surface area.

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Year:  1976        PMID: 1085404

Source DB:  PubMed          Journal:  Med J Aust        ISSN: 0025-729X            Impact factor:   7.738


  2 in total

1.  An indication of possible impending toxicity during moderately high dose methotrexate infusions.

Authors:  J W Paxton; E J Stephens; H F Wood
Journal:  Br J Clin Pharmacol       Date:  1978-12       Impact factor: 4.335

2.  The protein binding of methotrexate by the serum of normal subjects.

Authors:  W H Steele; J R Lawrence; J F Stuart; C A McNeill
Journal:  Eur J Clin Pharmacol       Date:  1979-06-12       Impact factor: 2.953

  2 in total

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