Literature DB >> 10853674

Synthesis and biological activity of peptidyl aldehyde urokinase inhibitors.

S Y Tamura1, M I Weinhouse, C A Roberts, E A Goldman, K Masukawa, S M Anderson, C R Cohen, A E Bradbury, V T Bernardino, S A Dixon, M G Ma, T G Nolan, T K Brunck.   

Abstract

Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems.

Entities:  

Mesh:

Substances:

Year:  2000        PMID: 10853674     DOI: 10.1016/s0960-894x(00)00149-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Antimalarial activities of novel synthetic cysteine protease inhibitors.

Authors:  Belinda J Lee; Ajay Singh; Peggy Chiang; Scott J Kemp; Erick A Goldman; Michael I Weinhouse; George P Vlasuk; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

2.  Synthesis and Biological Activity of N-Sulfonyltripeptides with C-Terminal Arginine as Potential Serine Proteases Inhibitors.

Authors:  Agnieszka Markowska; Magdalena Bruzgo; Ewa Gorodkiewicz; Arkadiusz Surażyński
Journal:  Int J Pept Res Ther       Date:  2012-12-02       Impact factor: 1.931

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.