Literature DB >> 10852956

A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis.

M L Brown1, M P Ramprasad, P K Umeda, A Tanaka, Y Kobayashi, T Watanabe, H Shimoyamada, W L Kuo, R Li, R Song, W A Bradley, S H Gianturco.   

Abstract

We have cloned a human macrophage receptor that binds to apolipoprotein (apo)B48 of dietary triglyceride (TG)-rich lipoproteins. TG-rich lipoprotein uptake by the apoB48R rapidly converts macrophages and apoB48R-transfected Chinese hamster ovary cells in vitro into lipid-filled foam cells, as seen in atherosclerotic lesions. The apoB48R cDNA (3,744 bp) encodes a protein with no known homologs. Its approximately 3.8-kb mRNA is expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Immunohistochemistry shows the apoB48R is in human atherosclerotic lesion foam cells. Normally, the apoB48R may provide essential lipids to reticuloendothelial cells. If overwhelmed, foam cell formation, endothelial dysfunction, and atherothrombogenesis may ensue, a mechanism for cardiovascular disease risk of elevated TG.

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Year:  2000        PMID： 10852956      PMCID： PMC16572          DOI： 10.1073/pnas.120184097

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Antipeptide antibodies reveal interrelationships of MBP 200 and MBP 235: unique apoB-specific receptors for triglyceride-rich lipoproteins on human monocyte-macrophages.

Authors:  W A Bradley; M L Brown; M P Ramprasad; R Li; R Song; S H Gianturco
Journal:  J Lipid Res       Date:  1999-04       Impact factor: 5.922

2.  The role of apolipoprotein processing in receptor recognition of VLDL.

Authors:  S H Gianturco; W A Bradley
Journal:  Methods Enzymol       Date:  1986       Impact factor: 1.600

Review 3.  A receptor-mediated pathway for cholesterol homeostasis.

Authors:  M S Brown; J L Goldstein
Journal:  Science       Date:  1986-04-04       Impact factor: 47.728

Review 4.  George Lyman Duff memorial lecture. Role of the liver in atherosclerosis.

Authors:  R J Havel
Journal:  Arteriosclerosis       Date:  1985 Nov-Dec

Review 5.  Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis.

Authors:  M S Brown; J L Goldstein
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

6.  Apolipoprotein E mediates uptake of Sf 100-400 hypertriglyceridemic very low density lipoproteins by the low density lipoprotein receptor pathway in normal human fibroblasts.

Authors:  S H Gianturco; A M Gotto; S L Hwang; J B Karlin; A H Lin; S C Prasad; W A Bradley
Journal:  J Biol Chem       Date:  1983-04-10       Impact factor: 5.157

7.  Abnormal effects of hypertriacylglycerolemic very low-density lipoproteins on 3-hydroxy-3-methylglutaryl-CoA reductase activity and viability of cultured bovine aortic endothelial cells.

Authors:  S H Gianturco; S G Eskin; L T Navarro; C J Lahart; L C Smith; A M Gotto
Journal:  Biochim Biophys Acta       Date:  1980-04-18

8.  Chylomicron remnant cholesteryl esters as the major constituent of very low density lipoproteins in plasma of cholesterol-fed rabbits.

Authors:  A C Ross; D B Zilversmit
Journal:  J Lipid Res       Date:  1977-03       Impact factor: 5.922

9.  Hypertriglyceridemic very low density lipoproteins induce triglyceride synthesis and accumulation in mouse peritoneal macrophages.

Authors:  S H Gianturco; W A Bradley; A M Gotto; J D Morrisett; D L Peavy
Journal:  J Clin Invest       Date:  1982-07       Impact factor: 14.808

10.  Low-density lipoprotein receptor binding determinants switch from apolipoprotein E to apolipoprotein B during conversion of hypertriglyceridemic very-low-density lipoprotein to low-density lipoproteins.

Authors:  W A Bradley; S L Hwang; J B Karlin; A H Lin; S C Prasad; A M Gotto; S H Gianturco
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157
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  15 in total

Review 1.  Role of triglyceride-rich lipoproteins in diabetic nephropathy.

Authors:  John C Rutledge; Kit F Ng; Hnin H Aung; Dennis W Wilson
Journal:  Nat Rev Nephrol       Date:  2010-05-04       Impact factor: 28.314

Review 2.  Diabetes: mellitus or lipidus?

Authors:  E Shafrir; I Raz
Journal:  Diabetologia       Date:  2003-03-14       Impact factor: 10.122

3.  Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.

Authors:  Pei Yu; Ting Xiong; Christine B Tenedero; Paul Lebeau; Ran Ni; Melissa E MacDonald; Peter L Gross; Richard C Austin; Bernardo L Trigatti
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-11-21       Impact factor: 8.311

4.  Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia.

Authors:  Yuko Fujita; Yoichi Ezura; Hideaki Bujo; Toshiaki Nakajima; Kaneo Takahashi; Kouhei Kamimura; Yasuhiko Iino; Yasuo Katayama; Yasushi Saito; Mitsuru Emi
Journal:  J Hum Genet       Date:  2005-04-14       Impact factor: 3.172

Review 5.  Mechanisms linking nonalcoholic fatty liver disease with coronary artery disease.

Authors:  W Nseir; A Shalata; A Marmor; N Assy
Journal:  Dig Dis Sci       Date:  2011-06-08       Impact factor: 3.199

6.  Comparison of diets high in monounsaturated versus polyunsaturated fatty acid on postprandial lipoproteins in diabetes.

Authors:  C Madigan; M Ryan; D Owens; P Collins; G H Tomkin
Journal:  Ir J Med Sci       Date:  2005 Jan-Mar       Impact factor: 1.568

7.  Utilization of triacylglycerol-rich lipoproteins by the working rat heart: routes of uptake and metabolic fates.

Authors:  You-Guo Niu; David Hauton; Rhys D Evans
Journal:  J Physiol       Date:  2004-04-30       Impact factor: 5.182

8.  Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage.

Authors:  Chih-Hao Lee; Kihwa Kang; Isaac R Mehl; Russell Nofsinger; William A Alaynick; Ling-Wa Chong; John M Rosenfeld; Ronald M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-07       Impact factor: 11.205

9.  Eleven loci with new reproducible genetic associations with allergic disease risk.

Authors:  Manuel A R Ferreira; Judith M Vonk; Hansjörg Baurecht; Ingo Marenholz; Chao Tian; Joshua D Hoffman; Quinta Helmer; Annika Tillander; Vilhelmina Ullemar; Yi Lu; Franz Rüschendorf; David A Hinds; Norbert Hübner; Stephan Weidinger; Patrik K E Magnusson; Eric Jorgenson; Young-Ae Lee; Dorret I Boomsma; Robert Karlsson; Catarina Almqvist; Gerard H Koppelman; Lavinia Paternoster
Journal:  J Allergy Clin Immunol       Date:  2018-04-19       Impact factor: 10.793

10.  Very-low-density lipoprotein: complex particles in cardiac energy metabolism.

Authors:  You-Guo Niu; Rhys D Evans
Journal:  J Lipids       Date:  2011-07-03
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