Literature DB >> 10852894

In vivo splicing and functional characterization of Mycobacterium leprae RecA.

K Frischkorn1, B Springer, E C Böttger, E O Davis, M J Colston, P Sander.   

Abstract

The RecA proteins from Mycobacterium tuberculosis and Mycobacterium leprae contain inteins. In contrast to the M. tuberculosis RecA, the M. leprae RecA is not spliced in Escherichia coli. We demonstrate here that M. leprae RecA is functionally spliced in Mycobacterium smegmatis and produces resistance toward DNA-damaging agents and homologous recombination.

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Year:  2000        PMID： 10852894      PMCID： PMC101971          DOI： 10.1128/JB.182.12.3590-3592.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  17 in total

1.  Protein splicing in the maturation of M. tuberculosis recA protein: a mechanism for tolerating a novel class of intervening sequence.

Authors:  E O Davis; P J Jenner; P C Brooks; M J Colston; S G Sedgwick
Journal:  Cell       Date:  1992-10-16       Impact factor: 41.582

2.  rpsL+: a dominant selectable marker for gene replacement in mycobacteria.

Authors:  P Sander; A Meier; E C Böttger
Journal:  Mol Microbiol       Date:  1995-06       Impact factor: 3.501

Review 3.  The ins and outs of protein splicing elements.

Authors:  M J Colston; E O Davis
Journal:  Mol Microbiol       Date:  1994-05       Impact factor: 3.501

Review 4.  Biochemistry of homologous recombination in Escherichia coli.

Authors:  S C Kowalczykowski; D A Dixon; A K Eggleston; S D Lauder; W M Rehrauer
Journal:  Microbiol Rev       Date:  1994-09

5.  Molecular structure of a gene, VMA1, encoding the catalytic subunit of H(+)-translocating adenosine triphosphatase from vacuolar membranes of Saccharomyces cerevisiae.

Authors:  R Hirata; Y Ohsumk; A Nakano; H Kawasaki; K Suzuki; Y Anraku
Journal:  J Biol Chem       Date:  1990-04-25       Impact factor: 5.157

6.  Intervening sequences in an Archaea DNA polymerase gene.

Authors:  F B Perler; D G Comb; W E Jack; L S Moran; B Qiang; R B Kucera; J Benner; B E Slatko; D O Nwankwo; S K Hempstead
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

7.  Construction and complementation of a recA deletion mutant of Mycobacterium smegmatis reveals that the intein in Mycobacterium tuberculosis recA does not affect RecA function.

Authors:  K G Papavinasasundaram; M J Colston; E O Davis
Journal:  Mol Microbiol       Date:  1998-11       Impact factor: 3.501

8.  Transformation of mycobacterial species using hygromycin resistance as selectable marker.

Authors:  T R Garbe; J Barathi; S Barnini; Y Zhang; C Abou-Zeid; D Tang; R Mukherjee; D B Young
Journal:  Microbiology       Date:  1994-01       Impact factor: 2.777

9.  Novel structure of the recA locus of Mycobacterium tuberculosis implies processing of the gene product.

Authors:  E O Davis; S G Sedgwick; M J Colston
Journal:  J Bacteriol       Date:  1991-09       Impact factor: 3.490

10.  Evidence of selection for protein introns in the recAs of pathogenic mycobacteria.

Authors:  E O Davis; H S Thangaraj; P C Brooks; M J Colston
Journal:  EMBO J       Date:  1994-02-01       Impact factor: 11.598
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  4 in total

1.  Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonuclease.

Authors:  Pawan Singh; Pankaj Tripathi; George H Silva; Alfred Pingoud; K Muniyappa
Journal:  J Biol Chem       Date:  2009-07-15       Impact factor: 5.157

Review 2.  Inteins: Localized Distribution, Gene Regulation, and Protein Engineering for Biological Applications.

Authors:  Theetha L Pavankumar
Journal:  Microorganisms       Date:  2018-02-28

3.  Tuberculosis vaccine strain Mycobacterium bovis BCG Russia is a natural recA mutant.

Authors:  Peter M Keller; Erik C Böttger; Peter Sander
Journal:  BMC Microbiol       Date:  2008-07-17       Impact factor: 3.605

Review 4.  Intein Inhibitors as Novel Antimicrobials: Protein Splicing in Human Pathogens, Screening Methods, and Off-Target Considerations.

Authors:  Diana A Wall; Seanan P Tarrant; Chunyu Wang; Kenneth V Mills; Christopher W Lennon
Journal:  Front Mol Biosci       Date:  2021-10-07
  4 in total

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