BACKGROUND: The role of changes in peri-operative blood lactate levels in recipients of living-related liver transplants has not yet been clarified. METHODS: Forty-three recipients were included in this study. Blood lactate, plasma total bilirubin, aminotransferase, body temperature, and gastric mucosal PCO2 levels were measured at six time points during surgery: just before the initiation of surgery, just after dissection of the hepatic vasculature, at the end of the anhepatic phase, and 30, 60, and 120 min after reperfusion. We calculated the rate of lactate accumulation during the pre-anhepatic and anhepatic phases and the elimination rate during reperfusion (neohepatic phase), and examined the correlation between these results and the clinical findings. RESULTS: The rate of lactate elimination during the neohepatic phase was correlated with the ratio of graft weight to standard liver volume (P<0.0001). There was also a significant correlation between the rate of lactate accumulation during the pre-anhepatic phase and the preoperative total bilirubin levels (P=0.0008). CONCLUSIONS: Each pre-anhepatic, anhepatic, and neohepatic phase had a characteristic blood lactate profile. The graft size strongly affected lactate levels during the early neohepatic phase.
BACKGROUND: The role of changes in peri-operative blood lactate levels in recipients of living-related liver transplants has not yet been clarified. METHODS: Forty-three recipients were included in this study. Blood lactate, plasma total bilirubin, aminotransferase, body temperature, and gastric mucosal PCO2 levels were measured at six time points during surgery: just before the initiation of surgery, just after dissection of the hepatic vasculature, at the end of the anhepatic phase, and 30, 60, and 120 min after reperfusion. We calculated the rate of lactate accumulation during the pre-anhepatic and anhepatic phases and the elimination rate during reperfusion (neohepatic phase), and examined the correlation between these results and the clinical findings. RESULTS: The rate of lactate elimination during the neohepatic phase was correlated with the ratio of graft weight to standard liver volume (P<0.0001). There was also a significant correlation between the rate of lactate accumulation during the pre-anhepatic phase and the preoperative total bilirubin levels (P=0.0008). CONCLUSIONS: Each pre-anhepatic, anhepatic, and neohepatic phase had a characteristic blood lactate profile. The graft size strongly affected lactate levels during the early neohepatic phase.
Authors: Margot Fodor; Lukas Lanser; Julia Hofmann; Giorgi Otarashvili; Marlene Pühringer; Benno Cardini; Rupert Oberhuber; Thomas Resch; Annemarie Weissenbacher; Manuel Maglione; Christian Margreiter; Philipp Zelger; Johannes D Pallua; Dietmar Öfner; Robert Sucher; Theresa Hautz; Stefan Schneeberger Journal: Transpl Int Date: 2022-05-16 Impact factor: 3.842
Authors: Zoe Schofield; Michelle Ac Reed; Philip N Newsome; David H Adams; Ulrich L Günther; Patricia F Lalor Journal: World J Gastroenterol Date: 2017-04-21 Impact factor: 5.742
Authors: Min Xu; Fangyu Zhou; Ola Ahmed; Lucy V Randle; Jun-Kyu Shin; Yuehui Zhu; Gundumi A Upadhya; Kathleen Byrnes; Brian Wong; Jae-Sung Kim; Yiing Lin; William C Chapman Journal: Transplant Direct Date: 2021-11-17