[The effect of protoplast formation on the antibiotic activity and composition of the actinomycin complex in a strain of Streptomyces galbus (F) subsp. achromogenes 695 and in its active variants].

Protoplasting and regeneration promoted variation by the antibiotic production property in Streptomyces galbus (F) subsp. achromogenes 695 and its active variants 695-3-2 and 695-3-2-206. Variant 695-P24 with the potency 2 times higher than that of the initial strain 695 revertants was selected. No variants lacking the capacity for biosynthesis of the main components of antibiotic A-695 were detected among the revertants still, protoplasting of strains 695-3-2-206 and 695-P24 resulted in formation of variants synthesizing new components of the actinomycin complex.