Literature DB >> 1085130

Antibacterial activity of delta9-tetrahydrocannabinol and cannabidiol.

B Van Klingeren, M Ten Ham.   

Abstract

The minimum inhibiting concentrations (MIC) of delta9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for staphylococci and streptococci in broth are in the range of 1-5 mug/ml. In the same range, both compounds are also bactericidal. In media containing 4% serum or 5% blood the antibacterial activity is strongly reduced (MIC 50 mug/ml). Gram-negative bacteria are resistant to THC and CBD.

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Year:  1976        PMID: 1085130     DOI: 10.1007/bf00399444

Source DB:  PubMed          Journal:  Antonie Van Leeuwenhoek        ISSN: 0003-6072            Impact factor:   2.271


  6 in total

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Authors:  E STEERS; E L FOLTZ; B S GRAVES
Journal:  Antibiot Chemother (Northfield)       Date:  1959-05

2.  Physiochemical properties, solubility, and protein binding of delta9-tetrahydrocannabinol.

Authors:  E R Garrett; C A Hunt
Journal:  J Pharm Sci       Date:  1974-07       Impact factor: 3.534

3.  On the metabolism of tritium-labelled 1-tetrahydrocannabinol in the rabbit.

Authors:  S Agurell; I M Nilsson; A Ohlsson; F Sandberg
Journal:  Biochem Pharmacol       Date:  1970-04       Impact factor: 5.858

4.  [Hemp (Cannabis sativa)--antibiotic drugs. II. Method & results of bacteriological experiments & preliminary clinical experience].

Authors:  Z KREJCI
Journal:  Pharmazie       Date:  1958-03       Impact factor: 1.267

5.  [Hemp (Cannabis sativa); antibiotic drug. I. Hemp in the old & popular medicine].

Authors:  J KABELIK
Journal:  Pharmazie       Date:  1957-07       Impact factor: 1.267

6.  [A sedative and antibacterial active agent from the German hemp (Cannabis sativa)].

Authors:  O E SCHULTZ; G HAFFNER
Journal:  Z Naturforsch B       Date:  1959-02       Impact factor: 1.047

  6 in total
  18 in total

Review 1.  Topical Antibiofilm Agents With Potential Utility in the Treatment of Chronic Rhinosinusitis: A Narrative Review.

Authors:  Samuel J M Hale; Brett Wagner Mackenzie; Christian A Lux; Kristi Biswas; Raymond Kim; Richard G Douglas
Journal:  Front Pharmacol       Date:  2022-06-13       Impact factor: 5.988

2.  Cannabis sativa CBD Extract Shows Promising Antibacterial Activity against Salmonella typhimurium and S. newington.

Authors:  Logan Gildea; Joseph Atia Ayariga; Olufemi S Ajayi; Junhuan Xu; Robert Villafane; Michelle Samuel-Foo
Journal:  Molecules       Date:  2022-04-21       Impact factor: 4.927

Review 3.  Pharmacokinetics and pharmacodynamics of cannabinoids.

Authors:  Franjo Grotenhermen
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

Review 4.  Cannabis and Cannabinoids in Reproduction and Fertility: Where We Stand.

Authors:  Bruno M Fonseca; Irene Rebelo
Journal:  Reprod Sci       Date:  2021-05-10       Impact factor: 2.924

5.  Cannabidiol Reduces Leukemic Cell Size - But Is It Important?

Authors:  Nikoletta Kalenderoglou; Tara Macpherson; Karen L Wright
Journal:  Front Pharmacol       Date:  2017-03-24       Impact factor: 5.810

6.  Cannabidiol Is a Novel Modulator of Bacterial Membrane Vesicles.

Authors:  Uchini S Kosgodage; Paul Matewele; Brigitte Awamaria; Igor Kraev; Purva Warde; Giulia Mastroianni; Alistair V Nunn; Geoffrey W Guy; Jimmy D Bell; Jameel M Inal; Sigrun Lange
Journal:  Front Cell Infect Microbiol       Date:  2019-09-10       Impact factor: 5.293

7.  Cannabidiol is an effective helper compound in combination with bacitracin to kill Gram-positive bacteria.

Authors:  Claes Søndergaard Wassmann; Peter Højrup; Janne Kudsk Klitgaard
Journal:  Sci Rep       Date:  2020-03-05       Impact factor: 4.379

8.  The antimicrobial potential of cannabidiol.

Authors:  Mark A T Blaskovich; Angela M Kavanagh; Alysha G Elliott; Bing Zhang; Soumya Ramu; Maite Amado; Gabrielle J Lowe; Alexandra O Hinton; Do Minh Thu Pham; Johannes Zuegg; Neil Beare; Diana Quach; Marc D Sharp; Joe Pogliano; Ashleigh P Rogers; Dena Lyras; Lendl Tan; Nicholas P West; David W Crawford; Marnie L Peterson; Matthew Callahan; Michael Thurn
Journal:  Commun Biol       Date:  2021-01-19

Review 9.  The antimicrobial effect behind Cannabis sativa.

Authors:  Laureano Schofs; Mónica D Sparo; Sergio F Sánchez Bruni
Journal:  Pharmacol Res Perspect       Date:  2021-04

10.  Comparative assessment of antimicrobial, antiradical and cytotoxic activities of cannabidiol and its propyl analogue cannabidivarin.

Authors:  Chiara Russo; Margherita Lavorgna; Roberta Nugnes; Elena Orlo; Marina Isidori
Journal:  Sci Rep       Date:  2021-11-18       Impact factor: 4.379

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