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Literature DB >> 10851196

Allosteric nucleic acid catalysts.

Abstract

Endowing nucleic acid catalysts with allosteric properties provides new prospects for RNA and DNA as controllable therapeutic agents or as sensors of their cognate effector compounds. The ability to engineer RNA catalysts that are allosterically regulated by effector binding has been propelled by the union of modular rational design principles and powerful combinatorial strategies.

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Year: 2000 PMID： 10851196 DOI： 10.1016/s0959-440x(00)00090-7

Source DB: PubMed Journal: Curr Opin Struct Biol ISSN： 0959-440X Impact factor: 6.809

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Cited

25 in total

1. Cooperative binding of effectors by an allosteric ribozyme.

Authors: A M Jose; G A Soukup; R R Breaker
Journal: Nucleic Acids Res Date: 2001-04-01 Impact factor: 16.971

2. A general approach for the use of oligonucleotide effectors to regulate the catalysis of RNA-cleaving ribozymes and DNAzymes.

Authors: Dennis Y Wang; Beatrice H Y Lai; Anat R Feldman; Dipankar Sen
Journal: Nucleic Acids Res Date: 2002-04-15 Impact factor: 16.971

10. Kinetic analysis of aptazyme-regulated gene expression in a cell-free translation system: modeling of ligand-dependent and -independent expression.

Authors: Shungo Kobori; Norikazu Ichihashi; Yasuaki Kazuta; Tomoaki Matsuura; Tetsuya Yomo
Journal: RNA Date: 2012-06-25 Impact factor: 4.942

Allosteric nucleic acid catalysts.

1. Cooperative binding of effectors by an allosteric ribozyme.

2. A general approach for the use of oligonucleotide effectors to regulate the catalysis of RNA-cleaving ribozymes and DNAzymes.

3. Optimization and optimality of a short ribozyme ligase that joins non-Watson-Crick base pairings.

4. A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.

5. A versatile communication module for controlling RNA folding and catalysis.

6. On the evolution of primitive genetic codes.

7. Exploring the repertoire of RNA secondary motifs using graph theory; implications for RNA design.

8. A modular, bifunctional RNA that integrates itself into a target RNA.

Review 9. Rube Goldberg goes (ribo)nuclear? Molecular switches and sensors made from RNA.

10. Kinetic analysis of aptazyme-regulated gene expression in a cell-free translation system: modeling of ligand-dependent and -independent expression.