Literature DB >> 10851002

Synechocystis strain PCC 6803 cya2, a prokaryotic gene that encodes a guanylyl cyclase.

J A Ochoa De Alda1, G Ajlani, J Houmard.   

Abstract

Synechocystis strain PCC 6803 exhibits similar levels of cyclic AMP (cAMP) and cyclic GMP (cGMP). A thorough analysis of its genome showed that Cya2 (Sll0646) has all the sequence determinants required in terms of activity and purine specificity for being a guanylyl cyclase. Insertional mutagenesis of cya2 caused a marked reduction in cGMP content without altering the cAMP content. Thus, Cya2 represents the first example of a prokaryotic guanylyl cyclase.

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Year:  2000        PMID： 10851002      PMCID： PMC94558          DOI： 10.1128/JB.182.13.3839-3842.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  31 in total

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Authors:  C L Tucker; J H Hurley; T R Miller; J B Hurley
Journal:  Proc Natl Acad Sci U S A       Date:  1998-05-26       Impact factor: 11.205

4.  SMART, a simple modular architecture research tool: identification of signaling domains.

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Review 5.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

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  20 in total

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Review 9.  cGMP production in bacteria.

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