OBJECTIVE: In the search of new human genotoxic biomarkers, the single cell gel electrophoresis assay has been proposed as a sensible alternative. MATERIAL AND METHODS: This technique detects principally single strand breaks as well as alkali-labile and repair-retarded sites. RESULTS: Herein we present our experience using the single cell gel electrophoresis assay in human population studies, both occupationally and environmentally exposed. CONCLUSIONS: We discuss the assay feasibility as a genotoxic biomarker.
OBJECTIVE: In the search of new human genotoxic biomarkers, the single cell gel electrophoresis assay has been proposed as a sensible alternative. MATERIAL AND METHODS: This technique detects principally single strand breaks as well as alkali-labile and repair-retarded sites. RESULTS: Herein we present our experience using the single cell gel electrophoresis assay in human population studies, both occupationally and environmentally exposed. CONCLUSIONS: We discuss the assay feasibility as a genotoxic biomarker.
Authors: R Chandirasekar; K Murugan; T Muralisankar; V Uthayakumar; R Jayakumar; K Mohan; C Vasugi; R Mathivanan; S Mekala; A Jagateesh; K Suresh Journal: Sci Rep Date: 2019-10-17 Impact factor: 4.379