Literature DB >> 10849758

Ceramide as an activator lipid of cathepsin D.

M Heinrich1, M Wickel, S Winoto-Morbach, W Schneider-Brachert, T Weber, J Brunner, P Saftig, C Peters, M Krönke, S Schütze.   

Abstract

We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger ceramide. Ceramide specifically binds to and induces CTSD proteolytic activity. A-SMase deficient cells derived from Niemann-Pick patients show decreased CTSD activity that was reconstituted by transfection with A-SMase cDNA. Ceramide accumulation in cells derived from A-ceramidase defective Farber patients correlates with enhanced CTSD activity. These findings suggest that A-SMase-derived ceramide targets endolysosomal CTSD.

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Year:  2000        PMID： 10849758     DOI： 10.1007/0-306-46826-3_33

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  35 in total

1.  nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis.

Authors:  Michal Levy; S Sianna Castillo; Tzipora Goldkorn
Journal:  Biochem Biophys Res Commun       Date:  2006-04-19       Impact factor: 3.575

2.  Cell biology: Stability in times of stress.

Authors:  Ibolya Horváth; László Vígh
Journal:  Nature       Date:  2010-01-28       Impact factor: 49.962

Review 3.  Phospholipid and sphingolipid metabolism in Leishmania.

Authors:  Kai Zhang; Stephen M Beverley
Journal:  Mol Biochem Parasitol       Date:  2009-12-23       Impact factor: 1.759

Review 4.  Intake of ω-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases.

Authors:  Tetsumori Yamashima; Tsuguhito Ota; Eishiro Mizukoshi; Hiroyuki Nakamura; Yasuhiko Yamamoto; Mitsuru Kikuchi; Tatsuya Yamashita; Shuichi Kaneko
Journal:  Adv Nutr       Date:  2020-11-16       Impact factor: 8.701

Review 5.  Sphingolipids and mitochondrial apoptosis.

Authors:  Gauri A Patwardhan; Levi J Beverly; Leah J Siskind
Journal:  J Bioenerg Biomembr       Date:  2016-04       Impact factor: 2.945

Review 6.  Ceramide-orchestrated signalling in cancer cells.

Authors:  Samy A F Morad; Myles C Cabot
Journal:  Nat Rev Cancer       Date:  2012-12-13       Impact factor: 60.716

7.  High activity of acid sphingomyelinase in major depression.

Authors:  J Kornhuber; A Medlin; S Bleich; V Jendrossek; A W Henkel; J Wiltfang; E Gulbins
Journal:  J Neural Transm (Vienna)       Date:  2005-11       Impact factor: 3.575

8.  Roles of sphingosine 1-phosphate on tumorigenesis.

Authors:  Yuan-Li Huang; Wei-Pang Huang; Hsinyu Lee
Journal:  World J Biol Chem       Date:  2011-02-26

9.  Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.

Authors:  Lonnie Schneider; Jianhua Zhang
Journal:  Mol Neurodegener       Date:  2010-04-13       Impact factor: 14.195

10.  Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide.

Authors:  Anna Cantalupo; Linda Sasset; Antonella Gargiulo; Luisa Rubinelli; Ilaria Del Gaudio; Domenico Benvenuto; Christian Wadsack; Xiang-Chen Jiang; Maria Rosaria Bucci; Annarita Di Lorenzo
Journal:  Hypertension       Date:  2020-03-16       Impact factor: 10.190
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