BACKGROUND: The effect of renal transplantation on pregnancy in Irish women not receiving CyA has been reported previously. AIM: To examine all pregnancies occurring in Irish female renal transplant recipients since the introduction of CyA. METHODS: Using a community based approach, we identified 29 pregnancies in 19 women, aged between 16 and 45, mean age 30.3 years. RESULTS: These pregnancies ended in four miscarriages (13%), two intra-uterine deaths (6.9%) and 23 live births (79.3%). Of these live births, 73.9% were premature (< or = 36 weeks) and 65.2% were of low birth weight (< 2500 g). Admission to the neonatal intensive care was necessary in 61%, and two babies (8.7%) died in the neonatal period. Mean gestational age was 34 weeks, and mean birth weight was 2190 g. There was no change in graft function during pregnancy, with a small rise in serum creatinine post-partum (+9.64 mumol/L). The renal graft failed in three women (15.8%) by the end of the follow-up period. Compared with the precyclosporine era, the live birth rate was higher (79.3% versus 58%) with a trend towards lower birth weight and shorter gestation. CONCLUSION: Renal transplantation with CyA use is not a contraindication to pregnancy, but it is associated with increased risk, especially when the serum creatinine is > 175 mumol/L.
BACKGROUND: The effect of renal transplantation on pregnancy in Irish women not receiving CyA has been reported previously. AIM: To examine all pregnancies occurring in Irish female renal transplant recipients since the introduction of CyA. METHODS: Using a community based approach, we identified 29 pregnancies in 19 women, aged between 16 and 45, mean age 30.3 years. RESULTS: These pregnancies ended in four miscarriages (13%), two intra-uterine deaths (6.9%) and 23 live births (79.3%). Of these live births, 73.9% were premature (< or = 36 weeks) and 65.2% were of low birth weight (< 2500 g). Admission to the neonatal intensive care was necessary in 61%, and two babies (8.7%) died in the neonatal period. Mean gestational age was 34 weeks, and mean birth weight was 2190 g. There was no change in graft function during pregnancy, with a small rise in serum creatinine post-partum (+9.64 mumol/L). The renal graft failed in three women (15.8%) by the end of the follow-up period. Compared with the precyclosporine era, the live birth rate was higher (79.3% versus 58%) with a trend towards lower birth weight and shorter gestation. CONCLUSION: Renal transplantation with CyA use is not a contraindication to pregnancy, but it is associated with increased risk, especially when the serum creatinine is > 175 mumol/L.
Authors: V T Armenti; K M Ahlswede; B A Ahlswede; J R Cater; B E Jarrell; M J Mortiz; J F Burke Journal: Transplantation Date: 1995-02-27 Impact factor: 4.939
Authors: A Marushak; T Weber; J Bock; S A Birkeland; H E Hansen; J Klebe; K Kristoffersen; K Rasmussen; K Olgaard Journal: Acta Obstet Gynecol Scand Date: 1986 Impact factor: 3.636
Authors: G Rizzoni; J H Ehrich; M Broyer; F P Brunner; H Brynger; W Fassbinder; W Geerlings; N H Selwood; G Tufveson; A J Wing Journal: Nephrol Dial Transplant Date: 1992 Impact factor: 5.992
Authors: Marleen C van Buren; Margriet Gosselink; Henk Groen; Henk van Hamersvelt; Margriet de Jong; Martin H de Borst; Robert Zietse; Jacqueline van de Wetering; A Titia Lely Journal: Transplantation Date: 2022-08-27 Impact factor: 5.385
Authors: Silvi Shah; Annette L Christianson; Prasoon Verma; Karthikeyan Meganathan; Anthony C Leonard; Daniel P Schauer; Charuhas V Thakar Journal: PLoS One Date: 2019-08-09 Impact factor: 3.240
Authors: Marleen C van Buren; Anouk Schellekens; T Katrien J Groenhof; Franka van Reekum; Jacqueline van de Wetering; Nina D Paauw; A Titia Lely Journal: Transplantation Date: 2020-08 Impact factor: 5.385