Literature DB >> 10843674

Analysis of the diversity of a sheep antibody repertoire as revealed from a bacteriophage display library.

K A Charlton1, S Moyle, A J Porter, W J Harris.   

Abstract

We have applied bacteriophage display technology to construct and analyze the diversity of an IgG library of >1 x 108 clones from an adult sheep immunized against the hapten atrazine. We have identified eight new VH gene families (VH2-VH9) and five new Vkappa gene families (VkappaV-VkappaIX). The heavy and kappa light chain variable region gene loci were found to be far more diverse than previously thought.

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Year:  2000        PMID： 10843674     DOI： 10.4049/jimmunol.164.12.6221

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  7 in total

1.  Generation of high-affinity chicken single-chain Fv antibody fragments for measurement of the Pseudonitzschia pungens toxin domoic acid.

Authors:  William J J Finlay; Iain Shaw; Joanna P Reilly; Marian Kane
Journal:  Appl Environ Microbiol       Date:  2006-05       Impact factor: 4.792

2.  A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana).

Authors:  Yongchen Guo; Yonghua Bao; Hui Wang; Xiaoxiang Hu; Zhihui Zhao; Ning Li; Yaofeng Zhao
Journal:  PLoS One       Date:  2011-02-25       Impact factor: 3.240

3.  Organization and Complexity of the Yak (Bos Grunniens) Immunoglobulin Loci.

Authors:  Mingli Wu; Haidong Zhao; Xiaoqin Tang; Wanxia Zhao; Xiaohua Yi; Qi Li; Xiuzhu Sun
Journal:  Front Immunol       Date:  2022-05-09       Impact factor: 8.786

4.  Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction.

Authors:  Mohammed M Al Qaraghuli; Soumya Palliyil; Gillian Broadbent; David C Cullen; Keith A Charlton; Andrew J Porter
Journal:  BMC Biotechnol       Date:  2015-10-24       Impact factor: 2.563

5.  High-sensitivity monoclonal antibodies specific for homoserine lactones protect mice from lethal Pseudomonas aeruginosa infections.

Authors:  Soumya Palliyil; Christina Downham; Ian Broadbent; Keith Charlton; Andrew J Porter
Journal:  Appl Environ Microbiol       Date:  2013-11-01       Impact factor: 4.792

6.  Immunoglobulin genomics in the guinea pig (Cavia porcellus).

Authors:  Yongchen Guo; Yonghua Bao; Qingwen Meng; Xiaoxiang Hu; Qingyong Meng; Liming Ren; Ning Li; Yaofeng Zhao
Journal:  PLoS One       Date:  2012-06-22       Impact factor: 3.240

7.  Synthesis of silymarin-selenium nanoparticle conjugate and examination of its biological activity in vitro.

Authors:  Sergey A Staroverov; Sergey V Kozlov; Alexander S Fomin; Konstantin P Gabalov; Vitaliy A Khanadeev; Dmitry A Soldatov; Ivan Yu Domnitsky; Lev A Dykman; Sergey V Akchurin; Olga I Guliy
Journal:  ADMET DMPK       Date:  2021-11-14
  7 in total

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