Literature DB >> 10843597

Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.

L M West1, P T Northcote, K A Hood, J H Miller, M J Page.   

Abstract

A new mycalamide, mycalamide D (3), has been isolated from the New Zealand marine sponge Mycale sp. This new metabolite, in which the C13-O-methyl group of mycalamide A (1) is replaced by a hydrogen atom, was found to be cytotoxic to a range of mammalian cell lines, with a potency approximately 20-fold less than that of 1.

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Year:  2000        PMID： 10843597     DOI： 10.1021/np9904511

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

1.  Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products.

Authors:  Xin Jiang; Noelle Williams; Jef K De Brabander
Journal:  Org Lett       Date:  2007-01-18       Impact factor: 6.005

2.  Studies toward the asymmetric synthesis of the right part of the mycalamides.

Authors:  H Marlon Zhong; Jeong-Hun Sohn; Viresh H Rawal
Journal:  J Org Chem       Date:  2007-01-19       Impact factor: 4.354

3.  Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B.

Authors:  Yongjun Dang; Tilman Schneider-Poetsch; Daniel E Eyler; John C Jewett; Shridhar Bhat; Viresh H Rawal; Rachel Green; Jun O Liu
Journal:  RNA       Date:  2011-06-21       Impact factor: 4.942

4.  Spatial and temporal variability of cytotoxic metabolites in populations of the New Zealand sponge Mycale hentscheli.

Authors:  M Page; L West; P Northcote; C Battershill; M Kelly
Journal:  J Chem Ecol       Date:  2005-05       Impact factor: 2.626

5.  Peloruside B, a potent antitumor macrolide from the New Zealand marine sponge Mycale hentscheli: isolation, structure, total synthesis, and bioactivity.

Authors:  A Jonathan Singh; Chun-Xiao Xu; Xiaoming Xu; Lyndon M West; Anja Wilmes; Ariane Chan; Ernest Hamel; John H Miller; Peter T Northcote; Arun K Ghosh
Journal:  J Org Chem       Date:  2010-01-01       Impact factor: 4.354

6.  Changes in bacterial communities of the marine sponge Mycale laxissima on transfer into aquaculture.

Authors:  Naglaa M Mohamed; Julie J Enticknap; Jayme E Lohr; Scott M McIntosh; Russell T Hill
Journal:  Appl Environ Microbiol       Date:  2007-12-21       Impact factor: 4.792

Review 7.  Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolide.

Authors:  John H Miller; A Jonathan Singh; Peter T Northcote
Journal:  Mar Drugs       Date:  2010-03-31       Impact factor: 5.118

8.  Culture of explants from the sponge Mycale cecilia to obtain bioactive mycalazal-type metabolites.

Authors:  Jose L Carballo; Benjamin Yañez; Eva Zubía; Maria J Ortega; Cristina Vega
Journal:  Mar Biotechnol (NY)       Date:  2009-11-26       Impact factor: 3.619

9.  Studies toward the unique pederin family member psymberin: full structure elucidation, two alternative total syntheses, and analogs.

Authors:  Yu Feng; Xin Jiang; Jef K De Brabander
Journal:  J Am Chem Soc       Date:  2012-10-04       Impact factor: 15.419

10.  Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin.

Authors:  Cheng-Yang Wu; Yu Feng; Eduardo R Cardenas; Noelle Williams; Paul E Floreancig; Jef K De Brabander; Michael G Roth
Journal:  J Am Chem Soc       Date:  2012-11-13       Impact factor: 15.419
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